Does turning patients during doxycycline pleurodesis improve success and comfort for malignant pleural effusion?
Impact of Patient Position on Chemical Pleurodesis by Chest Ultrasound
We will test whether turning people during doxycycline pleurodesis helps seal cancer-related pleural fluid and improves comfort.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Sex | All |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT07147270 on ClinicalTrials.gov |
What this trial studies
This interventional trial compares pleurodesis with oral doxycycline performed with patient rotation versus without rotation. Participants receive doxycycline pleurodesis and either are turned side-to-side and front-to-back for 30 minutes each or kept without rotation, with outcomes checked by chest ultrasound. Success of pleurodesis and patient comfort/pain are recorded, and standard exclusions (multiloculated fluid, prior failed pleurodesis, major organ failure, prolonged steroid/NSAID use) are applied. The single-center study is conducted at Ain Shams University Hospitals in Cairo.
Who should consider this trial
Good fit: Adults admitted to Ain Shams University with malignant pleural effusion who are candidates for doxycycline pleurodesis and do not meet exclusion criteria are ideal candidates.
Not a fit: Patients with multiloculated effusions, prior failed pleurodesis, significant liver/renal/heart failure, prolonged steroid or NSAID use, or those who refuse participation are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, the results could simplify care by showing rotation is unnecessary—reducing patient discomfort and staff effort—or else confirm that rotation improves sealing and comfort.
How similar studies have performed: Physiologic data and some clinical reports suggest tetracycline distributes rapidly throughout the pleural space so rotation likely has little effect, but direct randomized comparisons are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who will be admitted at Chest department, Ain-Shams University Hospitals with malignant pleural effusions candidate for pleurodesis Exclusion Criteria: * Multiloculated fluid * Previous failed pleurodesis * Liver failure * Renal failure * Congestive heart failure * Prolonged use of steroids or NSAIDs * Refusal to participate
Where this trial is running
Cairo
- Ain Shams university — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Hieba G Ezzelregal, MD
- Email: hiebagamal24@med.asu.edu.eg
- Phone: 01002041611
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.