Does turning patients during doxycycline pleurodesis improve success and comfort for malignant pleural effusion?
Official title: Impact of Patient Position on Chemical Pleurodesis by Chest Ultrasound
Run by Ain Shams University · NCT07147270 · Data updated 2026-11-12
We will test whether turning people during doxycycline pleurodesis helps seal cancer-related pleural fluid and improves comfort.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Status | Recruiting |
| Started | May 1, 2025 |
| Main results expected | December 2025 |
| Study ends | February 2026 |
| Registry record updated | August 29, 2025 |
| Trial ID | NCT07147270 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults admitted to Ain Shams University with malignant pleural effusion who are candidates for doxycycline pleurodesis and do not meet exclusion criteria are ideal candidates.
✕Probably not a fit
Patients with multiloculated effusions, prior failed pleurodesis, significant liver/renal/heart failure, prolonged steroid or NSAID use, or those who refuse participation are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional trial compares pleurodesis with oral doxycycline performed with patient rotation versus without rotation. Participants receive doxycycline pleurodesis and either are turned side-to-side and front-to-back for 30 minutes each or kept without rotation, with outcomes checked by chest ultrasound. Success of pleurodesis and patient comfort/pain are recorded, and standard exclusions (multiloculated fluid, prior failed pleurodesis, major organ failure, prolonged steroid/NSAID use) are applied. The single-center study is conducted at Ain Shams University Hospitals in Cairo.
Why it matters
Potential benefit: If successful, the results could simplify care by showing rotation is unnecessary—reducing patient discomfort and staff effort—or else confirm that rotation improves sealing and comfort.
How similar studies have gone: Physiologic data and some clinical reports suggest tetracycline distributes rapidly throughout the pleural space so rotation likely has little effect, but direct randomized comparisons are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who will be admitted at Chest department, Ain-Shams University Hospitals with malignant pleural effusions candidate for pleurodesis Exclusion Criteria: * Multiloculated fluid * Previous failed pleurodesis * Liver failure * Renal failure * Congestive heart failure * Prolonged use of steroids or NSAIDs * Refusal to participate
Where it's running
-
Ain Shams university
Cairo, Egypt Recruiting
Study contacts
- Study coordinator: Hieba G Ezzelregal, MD
- Email: hiebagamal24@med.asu.edu.eg
- Phone: 01002041611
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Fast TIL therapy for cancers that have spread to the pleura, including mesothelioma
This study will try a patient's own pleural T cells grown briefly in the lab and given into the chest with local IL-2 to treat people with malignant pleural effusions or pleural mesothelioma who have exhausted standard treatments.
-
Fast TIL therapy for cancers that have spread to the pleura
This treatment will try a patient's own pleural T cells, grown quickly in the lab and given into the chest with local IL-2, for adults whose cancer has spread to the pleura or for pleural mesothelioma.
-
Using NSAIDs for pain management during pleurodesis procedures
This study tests whether using a common pain reliever during pleurodesis can help reduce pain for patients with pneumothorax without causing more problems.
-
MT027 treatment for patients with pleural malignant tumors
This study is testing a new treatment called MT027 for patients with pleural malignant tumors to see if it's safe and how well it works after they have already received standard treatment.
-
Infusing tocilizumab into chest and abdominal cavities for advanced cancer patients
This study is testing if giving tocilizumab directly into the chest and abdomen can help advanced cancer patients with fluid buildup feel better and respond to treatment.
-
Registry for pleural fluid samples from lung cancer and infection patients
This study is collecting fluid samples from patients with lung cancer or lung infections to see if they can help create better tests and treatments for these conditions.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.