Does Hyaluronic Acid Help Dry Mouth?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will compare submucosal injections of hyaluronic acid versus placebo in adults with xerostomia over six months, with monthly follow-up visits. The trial will assess changes in dry mouth sensation, safety, duration of effect, and any shifts in salivary flow and pH. Participants won’t have at-home tasks and will be monitored for adverse events during clinic visits. The study uses a randomized, placebo-controlled design to determine if the treatment provides meaningful benefit beyond placebo. Primary information about long-term effectiveness and safety will guide future use if results are positive.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients over 18 years of age
* Patients reporting symptoms compatible with xerostomia for at least one year
* Patients who agree to cooperate in the study, comply with the follow-up plan, and sign the informed consent

Exclusion Criteria:

* Underage patients
* Pregnant patients
* Patients on antiplatelet or anticoagulant therapy
* Patients with a history of adverse reactions to hyaluronic acid infiltration
* Patients with active infectious diseases in the oral cavity
* Immunocompromised patients
* Patients with other active diseases affecting the oral mucosa
* Patients with uncontrolled autoimmune diseases
* Patients allergic to lidocaine and/or mepivacaine
* Patients undergoing active chemotherapy and/or radiotherapy for head and neck
* Non-cooperative patients (e.g., psychomotor dysfunctions and behavioral disorders)

Where it's running

• Hospital Odontologico Universidad de Barcelona
  Barcelona, Barcelona, Spain Recruiting

Study contacts

• Study coordinator: Veronica C Schiavo, DDs, Msc
• Email: v.schiavo@ub.edu
• Phone: 0034653515208

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.