Acupressure for dry mouth in head and neck cancer patients
Official title: Effect of Self-administered Acupressure for Improving Xerostomia in Head and Neck Cancer Patients: a Randomized Controlled Trial
Run by The University of Hong Kong · NCT06465628 · Data updated 2026-11-12
This study is testing if self-applied acupressure can help reduce dry mouth symptoms in people with head and neck cancer compared to just receiving oral health education.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 126 (estimated) |
| Sponsor | The University of Hong Kong Academic / other |
| Drugs / interventions | radiation, chemotherapy |
| Locations | 1 site (Hong Kong, Hong Kong) |
| Status | Recruiting |
| Started | December 1, 2024 |
| Main results expected | December 31, 2026 |
| Study ends | March 31, 2027 |
| Registry record updated | May 28, 2025 |
| Trial ID | NCT06465628 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who have been diagnosed with head and neck cancer and experience xerostomia after completing radiation therapy or chemoradiotherapy.
✕Probably not a fit
Patients with a history of xerostomia prior to cancer treatment or those who have recently practiced acupressure or acupuncture may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effects of self-administered acupressure on xerostomia, or dry mouth, in patients with head and neck cancer. Participants will be randomly assigned to receive either acupressure or oral health education, with the primary goal of assessing improvements in xerostomia symptoms. Secondary outcomes include quality of life and symptom severity evaluations. The study also aims to explore patient expectations and the acceptability of acupressure as a treatment option.
Why it matters
Potential benefit: If successful, this intervention could significantly improve the quality of life for head and neck cancer patients suffering from xerostomia.
How similar studies have gone: While there is limited research on self-administered acupressure for xerostomia, similar approaches in other conditions have shown promising results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * age ≥18 years; * able to give informed consent; * diagnosed with head and neck cancer (cancers in the head and neck region, e.g. oral cancer, nasopharyngeal cancer, oropharyngeal cancer, hypopharyngeal cancer, laryngeal cancer, sinus cancer, salivary gland cancer); * completed radiation therapy or chemoradiotherapy for at least 2 weeks; * complains of xerostomia after the treatment; * able to communicate in Cantonese or Mandarin. Exclusion Criteria: * history of xerostomia prior to head and neck cancer treatment (e.g., Sjögren Syndrome); * practiced acupressure or received acupuncture in the last 3 months; * having contraindications to acupressure, e.g. blood system disease (e.g., leukemia); pregnancy; lactating; upper or lower extremity deformities; infection or injuries at the acupoints. Those who are taking medications/alternative substances to treat xerostomia on a fixed dosage regimen in the past one month will not be excluded. \-
Where it's running
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Queen Mary Hospital
Hong Kong, Hong Kong, Hong Kong Recruiting
Study contacts
- Principal investigator: Denise Cheung, PhD — School of Nursing, the University of Hong Kong
- Study coordinator: Denise Cheung, PhD
- Email: denisest@hku.hk
- Phone: 39176673
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.