Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Acupressure for dry mouth in head and neck cancer patients

Official title: Effect of Self-administered Acupressure for Improving Xerostomia in Head and Neck Cancer Patients: a Randomized Controlled Trial

Run by The University of Hong Kong · NCT06465628 · Data updated 2026-11-12

This study is testing if self-applied acupressure can help reduce dry mouth symptoms in people with head and neck cancer compared to just receiving oral health education.

More Head and Neck Cancer trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment126 (estimated)
SponsorThe University of Hong Kong
Academic / other
Drugs / interventionsradiation, chemotherapy
Locations1 site (Hong Kong, Hong Kong)
StatusRecruiting
StartedDecember 1, 2024
Main results expectedDecember 31, 2026
Study endsMarch 31, 2027
Registry record updatedMay 28, 2025
Trial IDNCT06465628 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older who have been diagnosed with head and neck cancer and experience xerostomia after completing radiation therapy or chemoradiotherapy.

Probably not a fit

Patients with a history of xerostomia prior to cancer treatment or those who have recently practiced acupressure or acupuncture may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of self-administered acupressure on xerostomia, or dry mouth, in patients with head and neck cancer. Participants will be randomly assigned to receive either acupressure or oral health education, with the primary goal of assessing improvements in xerostomia symptoms. Secondary outcomes include quality of life and symptom severity evaluations. The study also aims to explore patient expectations and the acceptability of acupressure as a treatment option.

Why it matters

Potential benefit: If successful, this intervention could significantly improve the quality of life for head and neck cancer patients suffering from xerostomia.

How similar studies have gone: While there is limited research on self-administered acupressure for xerostomia, similar approaches in other conditions have shown promising results.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* age ≥18 years;
* able to give informed consent;
* diagnosed with head and neck cancer (cancers in the head and neck region, e.g. oral cancer, nasopharyngeal cancer, oropharyngeal cancer, hypopharyngeal cancer, laryngeal cancer, sinus cancer, salivary gland cancer);
* completed radiation therapy or chemoradiotherapy for at least 2 weeks;
* complains of xerostomia after the treatment;
* able to communicate in Cantonese or Mandarin.

Exclusion Criteria:

* history of xerostomia prior to head and neck cancer treatment (e.g., Sjögren Syndrome);
* practiced acupressure or received acupuncture in the last 3 months;
* having contraindications to acupressure, e.g. blood system disease (e.g., leukemia); pregnancy; lactating; upper or lower extremity deformities; infection or injuries at the acupoints.

Those who are taking medications/alternative substances to treat xerostomia on a fixed dosage regimen in the past one month will not be excluded.

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Where it's running

  • Queen Mary Hospital
    Hong Kong, Hong Kong, Hong Kong
    Recruiting

Study contacts

  • Principal investigator: Denise Cheung, PhD — School of Nursing, the University of Hong Kong
  • Study coordinator: Denise Cheung, PhD
  • Email: denisest@hku.hk
  • Phone: 39176673

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.