Does daily activity and exercise-induced irisin influence brain function and postoperative delirium in older adults?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates whether everyday physical activity and exercise-induced irisin might affect brain protection and the risk of postoperative delirium (POD) after surgery. Researchers will enroll adults aged 65 and older, categorizing them by preoperative activity level, and measure irisin in spinal fluid. POD and other postoperative complications will be tracked for five days after surgery to explore potential mediating effects of irisin on brain outcomes. The study is conducted at Peking University People's Hospital in Beijing under an observational framework with no experimental intervention beyond recording activity status.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged ≥ 65 years;
* Classified as ASA physical status I to III;
* Scheduled for non-cardiovascular surgery under spinal anesthesia or combined spinal-epidural anesthesia;
* Expected surgical duration of at least 2 hours;
* Voluntarily provide written informed consent and agree to participate in this study.

Exclusion Criteria:

* Significant change in exercise status within the past 7 days due to injury or other reasons;
* Contraindications to neuraxial anesthesia;
* Unable to assess cognitive function or Montreal Cognitive Assessment (MoCA) score \< 23;
* Preoperative diagnosis of delirium;
* History of traumatic brain injury or neurosurgery;
* Long-term opioid use or history of alcohol abuse;
* Planned surgery cancelled or changed (including intraoperative events that significantly alter the procedure or duration);
* Change in anesthesia method.

Where it's running

• Peking University People's Hospital
  Beijing, Beijing Municipality, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.