Disease progression and nutritional status in bronchiectasis
A Study of the Association Between Progression and Nutritional Status in Bronchiectasis
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · NCT06344000
The study will see if detailed nutritional measures (BMI, arm and calf circumference, skinfold thickness, and grip strength) relate to disease progression in adults with non-cystic fibrosis bronchiectasis.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (other) |
| Locations | 2 sites (Wuhan, Hubei and 1 other locations) |
| Trial ID | NCT06344000 on ClinicalTrials.gov |
What this trial studies
This observational cohort will enroll adults with non-cystic fibrosis bronchiectasis confirmed by imaging and obtain multiple nutrition-related measurements including BMI, upper arm and calf circumference, skinfold thickness, and grip strength. Investigators will record Bronchiectasis Severity Index components, clinical events such as exacerbations and hospitalizations, lung function, and microbial colonization over follow-up to track disease progression. The analysis will examine relationships between baseline and change-in nutritional indices and subsequent clinical outcomes. Participants with major organ failure, cystic fibrosis, prior lung transplant, pregnancy, or inability to consent are excluded.
Who should consider this trial
Good fit: Adults aged 18 or older with imaging-confirmed non-cystic fibrosis bronchiectasis who can provide informed consent and attend study visits are ideal candidates.
Not a fit: Patients with cystic fibrosis, prior lung transplant, serious nonpulmonary organ failure, pregnant or lactating women, or those unable to cooperate with assessments are unlikely to benefit from this observational protocol.
Why it matters
Potential benefit: If successful, the findings could help identify patients at risk of worsening disease so clinicians can target nutritional monitoring or interventions earlier.
How similar studies have performed: Prior studies have linked low BMI and reduced fat-free mass to worse outcomes and more hospitalizations in bronchiectasis and COPD, but comprehensive multi-measure nutritional profiling in bronchiectasis remains relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * Participants' pulmonary imaging findings and clinical presentation met the diagnostic criteria for bronchiectasis * Informed consent was signed Exclusion Criteria: * Age \<18 years * Does not meet the diagnostic criteria for bronchiectasis * Participants with cystic fibrosis or previous lung transplantation * Participants who are unable to cooperate with the study due to dysfunction of vital systems such as heart, brain, liver, and kidneys, or who are unable to participate in the study due to comorbid serious diseases * Pregnant or lactating females * Who are not able to provide informed consent or who refuse to participate in the clinical study
Where this trial is running
Wuhan, Hubei and 1 other locations
- Wuhan Union Hospital — Wuhan, Hubei, China (NOT_YET_RECRUITING)
- Wuhan Union Hospital,China — Wuhan, Hubei, China (RECRUITING)
Study contacts
- Principal investigator: Xiaorong Wang — Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Study coordinator: Xiaorong Wang
- Email: rong-100@163.com
- Phone: 18627195231
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Bronchiectasis, Nutrition