Disease progression and nutritional status in bronchiectasis
Official title: A Study of the Association Between Progression and Nutritional Status in Bronchiectasis
Run by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · NCT06344000 · Data updated 2026-11-12
The study will see if detailed nutritional measures (BMI, arm and calf circumference, skinfold thickness, and grip strength) relate to disease progression in adults with non-cystic fibrosis bronchiectasis.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Academic / other |
| Locations | 2 sites (Wuhan, Hubei and 1 other locations) |
| Status | Recruiting |
| Started | April 15, 2024 |
| Main results expected | April 15, 2027 |
| Study ends | April 15, 2027 |
| Registry record updated | September 25, 2025 |
| Trial ID | NCT06344000 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older with imaging-confirmed non-cystic fibrosis bronchiectasis who can provide informed consent and attend study visits are ideal candidates.
✕Probably not a fit
Patients with cystic fibrosis, prior lung transplant, serious nonpulmonary organ failure, pregnant or lactating women, or those unable to cooperate with assessments are unlikely to benefit from this observational protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational cohort will enroll adults with non-cystic fibrosis bronchiectasis confirmed by imaging and obtain multiple nutrition-related measurements including BMI, upper arm and calf circumference, skinfold thickness, and grip strength. Investigators will record Bronchiectasis Severity Index components, clinical events such as exacerbations and hospitalizations, lung function, and microbial colonization over follow-up to track disease progression. The analysis will examine relationships between baseline and change-in nutritional indices and subsequent clinical outcomes. Participants with major organ failure, cystic fibrosis, prior lung transplant, pregnancy, or inability to consent are excluded.
Why it matters
Potential benefit: If successful, the findings could help identify patients at risk of worsening disease so clinicians can target nutritional monitoring or interventions earlier.
How similar studies have gone: Prior studies have linked low BMI and reduced fat-free mass to worse outcomes and more hospitalizations in bronchiectasis and COPD, but comprehensive multi-measure nutritional profiling in bronchiectasis remains relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * Participants' pulmonary imaging findings and clinical presentation met the diagnostic criteria for bronchiectasis * Informed consent was signed Exclusion Criteria: * Age \<18 years * Does not meet the diagnostic criteria for bronchiectasis * Participants with cystic fibrosis or previous lung transplantation * Participants who are unable to cooperate with the study due to dysfunction of vital systems such as heart, brain, liver, and kidneys, or who are unable to participate in the study due to comorbid serious diseases * Pregnant or lactating females * Who are not able to provide informed consent or who refuse to participate in the clinical study
Where it's running
-
Wuhan Union Hospital,China
Wuhan, Hubei, China Recruiting -
Wuhan Union Hospital
Wuhan, Hubei, China Not yet recruiting
Study contacts
- Principal investigator: Xiaorong Wang — Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Study coordinator: Xiaorong Wang
- Email: rong-100@163.com
- Phone: 18627195231
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Chronic Respiratory Disease Participant Engagement
This study tests whether adults with long-term lung conditions can get comfortable with a clinical trials unit and research team before joining future trials.
-
Breathlessness in respiratory diseases: who feels it and why
This study tests how physiology, psychology, function, and breathing patterns relate to breathlessness in people with respiratory conditions compared with healthy controls.
-
Hypertonic saline inhalation for NTM lung disease
This trial tests whether starting inhaled 3% hypertonic saline early helps people with non-tuberculous mycobacterial lung disease feel better and clear bacteria better, compared with starting with normal saline first.
-
Azithromycin added to usual care to see if it lowers bronchiectasis flare-ups
This trial tests whether taking azithromycin daily for a year reduces bronchiectasis-related flare-ups in adults with non-cystic fibrosis bronchiectasis.
-
Bronchiectasis Phenotype Identification Model for Adults
This study tests a baseline classifier to categorize adults with non-cystic fibrosis bronchiectasis into phenotype groups using data collected over time.
-
BASE: Aiming to test a simple, objective way to gauge bronchiectasis severity and predict flare-ups
This study tests a new BASE framework to classify how severe non-cystic fibrosis bronchiectasis is right now and see if it can predict 12 months of worsening or flare-ups.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.