Digital rehabilitation for people with long-term COVID symptoms

Digital Rehabilitation With Cognitive Training, Physical Activity and Mindfulness for People With Post-acute COVID-19 Syndrome With Cognitive Impairment. REHABCOVID Project.

NA · Consorci Sanitari de Terrassa · NCT05846126

This study is testing a new program that combines mental exercises, physical activity, and mindfulness to see if it helps people with long-term COVID symptoms feel better and improve their overall well-being.

Quick facts

PhaseNA
Study typeInterventional
Enrollment158 (estimated)
Ages18 Years to 100 Years
SexAll
SponsorConsorci Sanitari de Terrassa (other)
Locations1 site (Terrassa)
Trial IDNCT05846126 on ClinicalTrials.gov

What this trial studies

This clinical trial aims to evaluate the effectiveness of a combined intervention of cognitive stimulation therapy, physical exercise, and mindfulness for individuals suffering from post-acute COVID-19 syndrome. Participants will be randomly assigned to one of two intervention groups or a control group, and the study will assess various outcomes including cognitive function, emotional well-being, physical health, and quality of life. Additionally, the trial will investigate the underlying molecular mechanisms and neuroplasticity changes associated with these interventions using advanced imaging techniques and biomarker analysis.

Who should consider this trial

Good fit: Ideal candidates are adults over 18 years old with persistent neurological symptoms and cognitive complaints at least 12 weeks post-COVID-19 infection.

Not a fit: Patients with pre-existing psychiatric or neurological disorders, or those with motor or sensory impairments that hinder participation in the rehabilitation program, may not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could significantly improve cognitive function and quality of life for patients suffering from long COVID.

How similar studies have performed: While the specific combination of interventions is novel, similar studies have shown promise in addressing cognitive impairments following viral infections.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Over 18 years old.
* Participants with a diagnosis of COVID-19 presenting persistent neurological symptoms at least 12 weeks after acute infection.
* They will have cognitive complaints
* Consent from a physician to engage in an exercise intervention

Exclusion Criteria:

* Established diagnosis before COVID-19 disease of psychiatric, neurological, developmental disorder, or systemic pathologies are known to cause cognitive deficits.
* Motor or sensory alterations that impede the rehabilitation program.

Where this trial is running

Terrassa

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Post-COVID Syndrome, COVID-19, Immersive Virtual Reality, Cognition, Cognitive Training, Physical Exercise, Mindfulness

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.