Digital intervention to reduce pain and opioid misuse

Mobile & Online-Based Interventions to Lessen Pain (MOBILE Relief) in People With Prescription Opioid Misuse

Phase 3 Interventional Stanford University · NCT05152134

This study is testing a new online program to help people with chronic pain reduce their pain and avoid misusing opioids.

Quick facts

PhasePhase 3
Study typeInterventional
Enrollment220 (estimated)
Ages18 Years and up
SexAll
SponsorStanford University Academic / other
Locations1 site (Palo Alto, California)
Trial IDNCT05152134 on ClinicalTrials.gov

What this trial studies

This international online trial evaluates the effectiveness of a digital pain relief intervention called 'Empowered Relief: On-Demand' in reducing pain and opioid misuse among individuals with chronic pain and opioid misuse. Participants will be randomly assigned to either the Empowered Relief intervention or a control group receiving general health education. The study will assess pain intensity, opioid craving, and misuse behaviors through electronic surveys at various time points. The goal is to determine the feasibility and effectiveness of this digital approach in managing chronic pain and opioid-related issues.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with chronic non-cancer pain and a history of prescription opioid misuse.

Not a fit: Patients with gross cognitive impairment or those currently enrolled in another study involving Empowered Relief may not benefit from this intervention.

Why it matters

Potential benefit: If successful, this intervention could provide a novel, accessible method for patients to manage chronic pain and reduce opioid misuse.

How similar studies have performed: Other studies have shown promise in using digital interventions for pain management, suggesting potential success for this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Male and females 18 years of age or older
* Chronic non-cancer pain (at least 6 months in duration)
* Average pain intensity of at least 3 on the PROMIS SFV1.0 Pain Intensity 1a
* Daily prescription opioid use (at least 10 morphine milliequivalent daily dose; MEDD) for at least 3 months
* Opioid misuse (at least 6 on the Current Opioid Misuse Measure; COMM)
* English fluency
* Internet access

Exclusion Criteria:

* Gross cognitive impairment
* Inability to complete study electronic surveys
* Cannot currently be enrolled in a study or trial with Empowered Relief as a treatment/intervention

Where this trial is running

Palo Alto, California

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Chronic PainOpioid MisuseOpioid Use Disorder
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.