Digestive tract effects after common antibiotics for urinary infections in young children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project follows infants and young children (3 months to under 3 years) treated as outpatients with single-agent amikacin, ceftriaxone, or cefixime for febrile urinary tract infections. Stool samples and clinical data will be collected from children whose parents provide consent, excluding hospitalized children, those on multiple antibiotics, or recent antibiotic users. The team will compare changes in gut microbiota and the acquisition or persistence of extended‑spectrum beta‑lactamase (ESBL)–producing Enterobacteriaceae after each antibiotic approach. Results are intended to inform antibiotic choices that minimize selection for highly resistant strains.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Infant and child (age ≥ 3 months and \<3 years)
* Patient treated for febrile urinary tract infection as monotherapy with amikacin IV, ceftriaxone (IV or IM) or cefixime PO \*
* Whose parents read and understood the newsletter and whose express consent was collected
* Patient affiliated to a social security scheme (Social Security or Universal Medical Coverage)

Exclusion Criteria:

* Child treated with more than one antibiotic (eg treatment with dual therapy ceftriaxone / cefotaxime and aminoglycoside)
* Antibiotherapy in progress or discontinued in the previous 7 days
* Hospitalized child
* Refusal of one of the parents

Where it's running

• Cabinet du Dr Benali
  Charenton-le-Pont, France Recruiting
• Cabinet du Dr Coicadan
  Chennevières-sur-Marne, France Recruiting
• Cabinet du Dr Corrard
  Combs-la-Ville, France Recruiting
• Cabinet du Dr Thollot
  Essey-lès-Nancy, France Recruiting
• Cabinet du Dr Deberdt
  Nogent-sur-Marne, France Recruiting
• Cabinet du Dr Wollner
  Nogent-sur-Marne, France Recruiting

Study contacts

• Principal investigator: Fouad MADHI, MD — CHI Créteil
• Study coordinator: Fouad Madhi, MD
• Email: fouad.madhi@chicreteil.fr
• Phone: +33157025422

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.