Different exercise programs to see how they affect muscle oxygenation in knee OA

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, randomized study enrolling 60 adults with knee osteoarthritis. Participants will be assigned to aerobic cycling, lower-limb strengthening, or a combination of both, with three supervised sessions per week for 6 weeks and a home stretching program. Assessments occur at baseline, week 3, week 6, and week 10 to evaluate muscle oxygenation and its relation to muscle strength. The trial uses online randomization and includes a 4-week post-intervention follow-up without supervised exercise.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 45 to 65 years.
* Body mass index (BMI) below 30 kg/m².
* Physician-diagnosed knee osteoarthritis according to the American College of Rheumatology (ACR) criteria.
* Bilateral knee osteoarthritis of Kellgren-Lawrence grade 2 or 3.
* Willingness to participate and provide informed consent.

Exclusion Criteria:

* Orthopedic or rheumatologic disease of the lower extremities, or arterial or venous disease.
* Uncontrolled hypertension, pulmonary disease, or diabetes.
* Neurological disease.
* Learning or cognitive impairment that may prevent participation.
* Knee extension deficit.
* Physical activity level above 600 MET-minutes/week, assessed using the International Physical Activity Questionnaire-Short Form (IPAQ-SF).
* Treatment for knee osteoarthritis within the previous 6 months, including physical therapy or injection.

Where it's running

• İstanbul University Cerrahpaşa, Faculty of Health Science, Physiotherapy and Rehabilitation Lab
  Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Ayşem Ecem Özdemir, Msc PT
• Email: ecemozdemir6@gmail.com
• Phone: +905375112777

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.