Knee injections for obese patients with knee arthritis
Official title: Comparison of Varying Doses of Steroid for Intra-articular Knee Injections
Run by Mayo Clinic · NCT06782529 · Data updated 2026-11-12
This study is testing whether low-dose corticosteroid injections can help obese patients with knee arthritis feel better and move easier, just like the standard-dose injections do.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 55 Years to 85 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Jacksonville, Florida) |
| Status | Recruiting |
| Started | January 24, 2025 |
| Main results expected | January 24, 2027 |
| Study ends | January 24, 2027 |
| Registry record updated | March 10, 2026 |
| Trial ID | NCT06782529 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are obese patients with a BMI of 30 kg/m2 or higher who have been diagnosed with knee osteoarthritis.
✕Probably not a fit
Patients with a BMI below 30 kg/m2 or those with uncontrolled diabetes may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of low-dose versus standard-dose corticosteroid injections in obese patients suffering from knee osteoarthritis. It aims to determine whether the low-dose treatment is non-inferior in improving pain and function compared to the standard dose. The study will involve patients with a body mass index (BMI) of 30 kg/m2 or higher who have radiographic evidence of knee osteoarthritis and are seeking steroid injections. Participants will be monitored for changes in knee pain and functional outcomes following treatment.
Why it matters
Potential benefit: If successful, this study could provide a safer and equally effective treatment option for obese patients with knee arthritis.
How similar studies have gone: Other studies have shown promising results with corticosteroid injections for knee osteoarthritis, but this specific comparison of low-dose versus standard-dose in obese patients is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: • Patients with BMI ≥30 kg/m2 and radiograph-proven knee osteoarthritis who are interested in receiving a steroid injection for knee arthritis. Exclusion Criteria: * BMI \< 30 kg/m2 * Uncontrolled diabetics with a hemoglobin A1c \> 8% * No other treatment within the time frame of the study. * Patients that are undergoing physical therapy at the time of the study.
Where it's running
-
Mayo Clinic in Florida
Jacksonville, Florida, United States Recruiting
Study contacts
- Principal investigator: Jeffrey P Nadwodny, DO — Mayo Clinic
- Study coordinator: Jeffrey P Nadwodny, DO
- Email: nadwodny.jeffrey@mayo.edu
- Phone: 904 953 6722
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.