Dietary changes to manage atopic dermatitis
Dietary Intervention on Atopy
This study is testing whether changing to a high-fat or plant-based diet can help people with atopic dermatitis manage their symptoms better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 110 (estimated) |
| Ages | 21 Years to 65 Years |
| Sex | All |
| Sponsor | National University of Singapore Academic / other |
| Locations | 1 site (Singapore, Singapore) |
| Trial ID | NCT06547372 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of dietary habits on atopic dermatitis (AD), a chronic inflammatory skin condition. It aims to explore how different dietary patterns, particularly high-fat versus plant-based diets, influence the severity and management of AD. Participants will be monitored for their adherence to specific dietary interventions while assessing the relationship between their diet and the symptoms of AD. The study is designed to provide insights that could lead to improved dietary recommendations for individuals suffering from this condition.
Who should consider this trial
Good fit: Ideal candidates are adults aged 21 to 65 with mild-to-moderate atopic dermatitis residing in Singapore.
Not a fit: Patients with severe atopic dermatitis or those with significant comorbidities may not benefit from this dietary intervention.
Why it matters
Potential benefit: If successful, this study could lead to dietary guidelines that significantly improve the management of atopic dermatitis for patients.
How similar studies have performed: Other studies have indicated a potential link between diet and allergic diseases, suggesting that this approach may yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Presence of current, mild-to-moderate atopic dermatitis/eczema at flexural areas 2. 21 to 65 years of age (inclusive) at screening 3. Must be English-literate and able to give informed consent in English 4. Be residing in Singapore and will not be travelling outside of Singapore during the study period 5. Reliable and willing to follow study procedures and be available for the duration of the study 6. Non-smokers (tobacco and e-cigarette) 7. Non-drinker (no regular or frequent consumption of alcohol) 8. Overtly healthy with no pre-existing medical conditions (e.g., diabetes, hypertension, cancer, blood disorders, degenerative/liver/autoimmune/immune/renal diseases, or psychiatric conditions) 9. No food allergies to test foods 10. No needle phobia 11. Be willing to follow the instruction provided by the investigators on the use of any moisturiser, cosmetics, and/or topical cream on the skin throughout the entire duration of the study. Exclusion Criteria: 1. Concurrent participation in other research studies 2. Pregnancy or lactating individuals 3. Known or ongoing psychiatric disorders within 3 years 4. Known severe nutritional deficiency 5. Vegetarian/vegans (as meat will be included in the diet) 6. Individuals who made a significant dietary change in the past 12 months 7. Having a pre-existing dietary restriction that would interfere with the adherence to a whole diet meal 8. Regular use of strong medication (western and/or traditional), therapies, and alternative medications 9. Regular nutritional supplements in the past 12 months Regular consumption of oral contraceptive pills and/or steroid hormones 10. Antibiotic use in the past 2 months 11. Any long-term hospitalisation or surgery during the 6 months before enrolment in study 12. Significant change in weight (+/- 5.0%) during the past month 13. History of bleeding diathesis or coagulopathy (or any bleeding disorders) 14. Having donated blood of more than 500 mL within 4 weeks of study enrolment
Where this trial is running
Singapore, Singapore
- National University of Singapore — Singapore, Singapore, Singapore (Recruiting)
Study contacts
- Principal investigator: Fook Tim CHEW, PhD — NUS Singapore
- Study coordinator: Mei Hui Liu, PhD
- Email: fstlmh@nus.edu.sg
- Phone: 65163523
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.