Diet patterns and gut health: effects of ketogenic, vegetarian, and habitual diets

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this 12-week study, healthy adults are randomized to follow a ketogenic diet, a vegetarian diet, or their usual mixed diet. Researchers will monitor adherence with dietary records and counseling, and collect blood and stool samples at baseline, week 4, week 8, and week 12. The study measures include body composition, transcriptomic profiles, cellular metabolism, blood biochemistry, and gut microbiome composition, with ketone levels tracked in the ketogenic group to confirm adherence. The goal is to see how macronutrient composition influences metabolic health, inflammation, and gene expression.

Why it matters

Who can join: the full rules

Inclusion Criteria:

In addition to the physical activity requirements described above, the study will include men and women aged 18-60 years with:

BMI not exceeding 40kg/m²

Habitual mixed diet prior to study enrollment

Normal blood pressure

* Exclusion Criteria:

Poprawiłem już \*\*Exclusion Criteria\*\* w poprzedniej odpowiedzi - wszystkie te kryteria już tam są wpisane. Oto pełna, ostateczna wersja z wszystkimi wskazanymi kryteriami wyłączenia:

\*\*\* \*\*Exclusion Criteria:\*\*

* Use of medications regulating \*\*glucose levels\*\* (e.g., metformin) or \*\*blood lipids\*\* (e.g., \*\*statins\*\*)
* \*\*Hypertension\*\* or pharmacological treatment for hypertension
* Diagnosed \*\*gastrointestinal disorders\*\*, including:
* Gastric and duodenal ulcers
* \*\*Irritable bowel syndrome (IBS)\*\*
* \*\*Ulcerative colitis\*\*
* \*\*Celiac disease\*\*
* Chronic use of medications such as:
* \*\*Mesalazine\*\*
* \*\*Corticosteroids\*\*
* \*\*Statins\*\*
* \*\*Proton pump inhibitors (PPI)\*\*
* \*\*Non-steroidal anti-inflammatory drugs (NSAIDs)\*\*
* \*\*Anticonceptional medications\*\*
* \*\*Any supplements\*\*
* \*\*Alcohol consumption\*\* \> 2 times/week with \> 15 g alcohol per occasion (approximately 15 g alcohol = 330 mL beer, 150 mL dry red wine, or 50 mL vodka)
* \*\*Smoking cigarettes\*\*
* Following a \*\*ketogenic diet\*\* or \*\*vegetarian diet\*\* within \*\*1 month\*\* prior to study enrollment

Where it's running

• Jaggielonian University
  Krakow, Poland Recruiting
• Pomeranian Medical University
  Szczecin, Poland Recruiting

Study contacts

• Principal investigator: Małgorzata M Michalczyk, Assistante professor — Institute of Sport Sciences, Jerzy Kukuczka Academy of Physical Education in Katowice
• Study coordinator: Małgorzata Magdalena Michalczyk, Assistante professor
• Email: m.michalczyk@awf.katowice.pl
• Phone: +48535016532

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Managing pasireotide-related high blood sugar in acromegaly with a ketogenic diet

  This study tests whether a very-low carbohydrate ketogenic diet can help lower HbA1c and fasting glucose in adults with acromegaly who develop high blood sugar while taking pasireotide.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT07866846

• Ketogenic Diet and Alcohol Intoxication: Can ketosis affect brain function and alcohol response

  This study tests whether a 4‑week ketogenic diet changes how the brain works and how the body handles alcohol in adults who drink regularly.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT07602270

• Ketogenic diet therapy for patients with acromegaly

  This study tests whether a ketogenic diet can help people with acromegaly lower their growth hormone levels and improve their quality of life compared to a Mediterranean diet.

  Recruiting Erasmus Medical Center · Rotterdam · NCT06949891

• Healthy Options At Pantries prompts healthier online pantry choices

  A digital nudge called HOAP is tested in online food pantries to see if it helps shoppers pick healthier items.

  Recruiting Northwestern University · Chicago, Illinois · NCT07729436

• Bioavailability of broccoli extract supplements in healthy adults

  This study tests how much glucoraphanin and sulforaphane from three broccoli extract versions are absorbed and excreted in healthy adults aged 18–60.

  Recruiting Oregon State University · Corvallis, Oregon · NCT07564674

• Fear of hypoglycemia in people with diabetes

  This study looks at how fear of low blood sugar affects how people with diabetes take their medications and manage their diet.

  Recruiting Bilecik Seyh Edebali Universitesi · Bilecik · NCT07329985

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.