Bioavailability of broccoli extract supplements in healthy adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares the bioavailability of three broccoli extract supplements containing glucoraphanin and myrosinase in generally healthy adults. Participants consume each version in separate 24-hour cycles, with blood and urine collected to measure glucoraphanin, sulforaphane, and metabolites. Diets are restricted to avoid cruciferous vegetables and certain supplements for one week before and during each cycle. The study uses a fixed sampling schedule to characterize absorption and excretion over 24 hours after each dose, with careful exclusion of smokers, pregnant individuals, and those with major illnesses. Lead sponsorship is from Oregon State University, with the study conducted at OSU in Corvallis, Oregon.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy adults, 18-60 years of age
* Willing to stop taking herbal and phytochemical (plant-based extract or phytochemical) supplements for 1 week prior to and during each study cycle
* Willing to stop cruciferous vegetable intake 1 week prior to and during each study cycle
* Must be able to give written informed consent

Exclusion Criteria:

* Body Mass Index (BMI) \<18.5 or \>30.0 kg/m2
* Tobacco use, including e-cigarettes, or smoking of any substance (e.g. cannabis) in the past three months
* Pregnancy, breastfeeding, or planning to become pregnant before completing the study
* Engaging in vigorous exercise more than 7 hours per week
* Have a significant acute or chronic illness such as cardiovascular disease, kidney or liver disease, diabetes, thyroid disorder, or radiation or chemotherapy treatment for cancer within the past five years
* Use of medications to control cholesterol (e.g. statins, cholestyramine) or fat absorption (e.g. orlistat)
* Have had bariatric surgery (e.g. gastric bypass, gastric banding, sleeve gastrectomy, etc.), other gastrointestinal procedure (e.g. cholecystectomy) or disorders (e.g. Crohn's disease, celiac disease, ulcerative colitis)
* Allergic to broccoli, moringa, mustard, or maitake mushrooms
* Weighs less than 110 pounds
* Diagnosis of sickle cell disease

Where it's running

• Oregon State University
  Corvallis, Oregon, United States Recruiting

Study contacts

• Principal investigator: Emily Ho, PhD — Oregon State University
• Study coordinator: Emily Ho, PhD
• Email: emily.ho@oregonstate.edu
• Phone: 541-737-9559

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.