Dexmedetomidine's effect on anesthesia during laparoscopic surgery
Effect of Dexmedetomidine on Sevoflurane Minimum Alveolar Concentration for Attenuating Adrenergic Response to CO2 Pneumoperitoneum: A Randomized Controlled Trial
PHASE4 · Fujian Provincial Hospital · NCT06575179
This study tests if giving dexmedetomidine during laparoscopic surgery can help reduce the amount of anesthesia needed and improve heart stability for patients.
Quick facts
| Phase | PHASE4 |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Sponsor | Fujian Provincial Hospital (other) |
| Locations | 1 site (Fuzhou, Fujian) |
| Trial ID | NCT06575179 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates how dexmedetomidine influences the minimum alveolar concentration blunting the adrenergic response (MAC-BAR) of sevoflurane in patients undergoing laparoscopic cholecystectomy. The study compares low-dose and high-dose dexmedetomidine to determine its effectiveness in reducing the anesthetic requirements needed to suppress the body's stress response to carbon dioxide pneumoperitoneum. Additionally, it evaluates the impact of dexmedetomidine on hemodynamic parameters during surgery. Participants will receive either dexmedetomidine or a saline placebo to assess the drug's potential benefits.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 18-45 undergoing elective laparoscopic cholecystectomy.
Not a fit: Patients with chronic pain, substance abuse history, or those who are pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to safer anesthesia practices with lower doses of sevoflurane, reducing postoperative complications.
How similar studies have performed: Other studies have shown promising results with dexmedetomidine in similar contexts, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 1\. Aged 18-45 years. * 2\. American Society of Anesthesiologists (ASA) grade I - II. * 3\. Patients undergoing elective laparoscopic cholecystectomy. Exclusion Criteria: * 1\. Inability to provide informed consent; * 2\. History of chronic pain or substance abuse; * 3\. Pregnancy; * 4\. Body mass index (BMI) ≥ 30 kg/m2; * 5\. Known allergies to the study medications; * 6\. Intake of medications within the last 72 hours that potential interfere with the determination of the MAC-BAR; * 7\. Any other condition deemed exclusionary by the investigators.
Where this trial is running
Fuzhou, Fujian
- Fujian Provincial Hospital — Fuzhou, Fujian, China (RECRUITING)
Study contacts
- Study coordinator: Yusheng Yao, MD&PhD
- Email: fjslyys@fjmu.edu.cn
- Phone: 13559939629
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Laparoscopic Cholecystectomy, dexmedetomidine, MAC-BAR, sevoflurane, laparoscopic surgery, α2-adrenergic receptor agonist