Dexmedetomidine versus midazolam for sedation during coronary artery bypass grafting
A Comparative Evaluation of Dexmedetomidine and Midazolam ınfusions With Respect to Postoperative Delirium in Patients Undergoing Coronary Artery Bypass Grafting
This trial will test whether using dexmedetomidine instead of midazolam during elective coronary artery bypass grafting lowers the chance of postoperative delirium in adults.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Cumhuriyet University Academic / other |
| Locations | 1 site (Sivas) |
| Trial ID | NCT07411794 on ClinicalTrials.gov |
What this trial studies
Adult patients scheduled for elective coronary artery bypass grafting are allocated into two groups of 30 to receive intraoperative infusion of either dexmedetomidine or midazolam alongside standard anesthesia. Demographic information and intraoperative measures such as heart rate, mean arterial pressure, SpO2, bispectral index, cerebral oxygenation, and pCO2 will be recorded at set intervals. Surgical duration, cardiopulmonary bypass time, recovery time, ICU length of stay, and the presence of delirium using the CAM-ICU will be documented. The primary comparison is the incidence of postoperative delirium between the two infusion groups.
Who should consider this trial
Good fit: Adults scheduled for elective CABG who can provide informed consent and do not have significant renal, hepatic, or neuropsychiatric disorders are the intended participants.
Not a fit: Patients with renal or hepatic impairment, preexisting neuropsychiatric disorders, those unable to consent, or those undergoing emergency/non-elective CABG are not likely to be eligible or to benefit from the interventions tested.
Why it matters
Potential benefit: If successful, using dexmedetomidine could lower rates of postoperative delirium and potentially shorten ICU stays after CABG.
How similar studies have performed: Previous trials and ICU studies have suggested dexmedetomidine can reduce delirium compared with benzodiazepines, though results have been mixed across settings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients scheduled for elective coronary artery bypass graft surgery. Exclusion Criteria: * Patients with renal disorders, * Patients with hepatic disorders, * Patients with neuropsychiatric disorders, * Patients whom informed consent could not be obtained * Patients who declined to participate in the study.
Where this trial is running
Sivas
- Sivas Cumhuriyet University — Sivas, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Oğuz Gündoğdu
- Email: droguzgundogdu@gmail.com
- Phone: +905545945469
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.