Dexamethasone versus metoclopramide to prevent nausea after cataract surgery
Efficacy of Dexamethasone Versus Metoclopramide for Prophylaxis of Nausea and Vomiting After Cataract Surgery: A Double-blind Randomized Controlled Study
This trial tests whether dexamethasone works better than metoclopramide at preventing nausea and vomiting after cataract surgery in adults aged 40-80.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 210 (estimated) |
| Ages | 40 Years to 80 Years |
| Sex | All |
| Sponsor | Alexandria University Academic / other |
| Locations | 1 site (Alexandria) |
| Trial ID | NCT07086118 on ClinicalTrials.gov |
What this trial studies
Adults aged 40-80 with ASA physical status I–III undergoing cataract surgery at Alexandria University will be assigned to receive dexamethasone, metoclopramide 10 mg, or normal saline around the time of surgery. Investigators will monitor patients in the postanesthesia care unit for postoperative nausea and vomiting (PONV), delays in discharge, and any ocular complications such as suprachoroidal hemorrhage. Patients with motion sickness, gastrointestinal disorders, current antiemetic use, prior postoperative vomiting, or allergy to the study drugs are excluded. The primary comparison is the incidence of PONV between the dexamethasone and metoclopramide groups.
Who should consider this trial
Good fit: Ideal candidates are adults 40-80 years old, ASA I–III, scheduled for cataract surgery who are not taking other antiemetics and have no history of motion sickness, significant gastrointestinal disease, or allergy to metoclopramide or dexamethasone.
Not a fit: Patients with a history of motion sickness, gastroesophageal reflux or other GI disorders, those already taking antiemetic medications, previous postoperative vomiting, or allergies to the study drugs are unlikely to qualify or benefit from this comparison.
Why it matters
Potential benefit: If successful, dexamethasone could reduce nausea and vomiting after cataract surgery, leading to fewer complications, faster discharges, and improved patient satisfaction.
How similar studies have performed: Previous studies have shown that steroids and dopamine antagonists can reduce PONV and dexamethasone has demonstrated benefit in other surgical settings, although serotonin antagonists are generally more effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: 40-80 years, both sexes. * ASA physical status class I to III. Exclusion Criteria: * history of motion sickness * patients with gastrointestinal disorders or gastro-oesophageal reflux * patients taking medications with known antiemetic activity * previous postoperative vomiting * allergy to bupivacaine * allergy to metoclopramide or dexamethasone
Where this trial is running
Alexandria
- Alexandria University — Alexandria, Egypt (Recruiting)
Study contacts
- Principal investigator: sarah m elgamal, MD — Alexandria University
- Study coordinator: sarah m elgamal, MD
- Email: sarahelgamal1990@yahoo.com
- Phone: 01005496440
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.