Dexamethasone to prolong spinal anesthesia for cesarean delivery
Official title: Role of Intravenous Dexamethasone in Prolonging the Duration of Sub-Arachnoid Block in Pregnant Patients Undergoing Lower Segment Cesarean Section
Run by Rawalpindi Medical College · NCT07088146 · Data updated 2026-11-12
This trial tests whether a single IV dose of dexamethasone given around an elective C-section helps spinal anesthesia and postoperative pain relief last longer than a placebo.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 16 Years to 40 Years |
| Sex | Women only |
| Enrollment | 110 (estimated) |
| Sponsor | Rawalpindi Medical College Academic / other |
| Locations | 1 site (Rawalpindi, Punjab Province) |
| Status | Recruiting |
| Started | July 20, 2025 |
| Main results expected | October 20, 2025 |
| Study ends | October 20, 2025 |
| Registry record updated | July 28, 2025 |
| Trial ID | NCT07088146 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are pregnant women scheduled for elective lower-segment cesarean delivery under spinal anesthesia who are ASA class II or higher and do not have diabetes, gestational diabetes, BMI >35, adrenal insufficiency, chronic steroid use, or allergies to the medication.
✕Probably not a fit
Patients with gestational diabetes or diabetes, BMI over 35, adrenal insufficiency, chronic steroid therapy, or allergy to dexamethasone are excluded and would not receive potential benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Pregnant women having elective lower-segment cesarean delivery under spinal (subarachnoid) anesthesia receive either intravenous dexamethasone or a placebo around the time of surgery, and the duration of the spinal block and postoperative analgesia is recorded. The intervention is intended as a perioperative adjuvant to extend sensory block time and reduce early postoperative pain. Eligible participants are ASA class II and above and must not have diabetes, gestational diabetes, BMI >35, adrenal insufficiency, chronic steroid use, or allergy to the study medication. The trial is conducted at a single center and compares time-to-regression of sensory block and analgesic requirements between the dexamethasone and placebo groups.
Why it matters
Potential benefit: If successful, this could lengthen spinal anesthesia and postoperative pain relief after cesarean delivery, reducing the need for additional pain medicines and improving early recovery and comfort.
How similar studies have gone: Previous perioperative studies show IV or perineural dexamethasone can prolong some nerve-block analgesia and reduce nausea, but evidence specifically for extending subarachnoid (spinal) block duration is limited and mixed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiologists (ASA) class: II and above. * Elective Cesarean section under Spinal Anesthesia. Exclusion Criteria: * Gestational diabetes * Body mass index \>35 kg/m2 * Diabetes mellitus * Adrenal insufficiency * Chronically receiving steroids * Allergic to study medications * Sensory block level less than T4
Where it's running
-
Benazir Bhutto Hospital Rawalpindi
Rawalpindi, Punjab Province, Pakistan Recruiting
Study contacts
- Study coordinator: Huda Tariq, MBBS
- Email: Huda8829@gmail.com
- Phone: +92-321-8829413
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.