Clinical trial Recruiting at 1 site Phase 4 Interventional Ages 16 to 40 Women only

Dexamethasone to prolong spinal anesthesia for cesarean delivery

Official title: Role of Intravenous Dexamethasone in Prolonging the Duration of Sub-Arachnoid Block in Pregnant Patients Undergoing Lower Segment Cesarean Section

Run by Rawalpindi Medical College · NCT07088146 · Data updated 2026-11-12

This trial tests whether a single IV dose of dexamethasone given around an elective C-section helps spinal anesthesia and postoperative pain relief last longer than a placebo.

Quick facts

PhasePhase 4
Study typeInterventional
Ages16 Years to 40 Years
SexWomen only
Enrollment110 (estimated)
SponsorRawalpindi Medical College
Academic / other
Locations1 site (Rawalpindi, Punjab Province)
StatusRecruiting
StartedJuly 20, 2025
Main results expectedOctober 20, 2025
Study endsOctober 20, 2025
Registry record updatedJuly 28, 2025
Trial IDNCT07088146 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are pregnant women scheduled for elective lower-segment cesarean delivery under spinal anesthesia who are ASA class II or higher and do not have diabetes, gestational diabetes, BMI >35, adrenal insufficiency, chronic steroid use, or allergies to the medication.

Probably not a fit

Patients with gestational diabetes or diabetes, BMI over 35, adrenal insufficiency, chronic steroid therapy, or allergy to dexamethasone are excluded and would not receive potential benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Pregnant women having elective lower-segment cesarean delivery under spinal (subarachnoid) anesthesia receive either intravenous dexamethasone or a placebo around the time of surgery, and the duration of the spinal block and postoperative analgesia is recorded. The intervention is intended as a perioperative adjuvant to extend sensory block time and reduce early postoperative pain. Eligible participants are ASA class II and above and must not have diabetes, gestational diabetes, BMI >35, adrenal insufficiency, chronic steroid use, or allergy to the study medication. The trial is conducted at a single center and compares time-to-regression of sensory block and analgesic requirements between the dexamethasone and placebo groups.

Why it matters

Potential benefit: If successful, this could lengthen spinal anesthesia and postoperative pain relief after cesarean delivery, reducing the need for additional pain medicines and improving early recovery and comfort.

How similar studies have gone: Previous perioperative studies show IV or perineural dexamethasone can prolong some nerve-block analgesia and reduce nausea, but evidence specifically for extending subarachnoid (spinal) block duration is limited and mixed.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* American Society of Anesthesiologists (ASA) class: II and above.
* Elective Cesarean section under Spinal Anesthesia.

Exclusion Criteria:

* Gestational diabetes
* Body mass index \>35 kg/m2
* Diabetes mellitus
* Adrenal insufficiency
* Chronically receiving steroids
* Allergic to study medications
* Sensory block level less than T4

Where it's running

  • Benazir Bhutto Hospital Rawalpindi
    Rawalpindi, Punjab Province, Pakistan
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.