Developing and validating a formula to detect major kidney events in people with decompensated cirrhosis and ascites

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on decompensated cirrhosis patients with ascites to develop and validate an equation that determines major adverse kidney events. It uses observational data from hospitalized adults and excludes those with prior AKI, liver or kidney transplant, or other major organ failure. The goal is to improve risk stratification for kidney-related outcomes by predicting major events such as progression to CKD or need for kidney-related interventions. The analysis will consider factors like baseline renal function and common risk factors to create a clinically usable scoring method. No interventional treatments are administered in this design.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients of cirrhosis with ascites with stable renal functions in last 7 days (variability in gfr \< 15 % and no AKI).

Exclusion Criteria:

1. Patients with age \<18 or more than 65 years
2. Obstructive uropathy or intrinsic kidney disease
3. Patients with multiorgan failure or requiring mechanical ventilation
4. Patients who had previously undergone Liver or Kidney transplant
5. Patients with missing laboratory measurements within 24 hours of admission
6. HCC
7. Pregnant
8. Lack of baseline serum creatinine
9. Need of renal replacement therapy
10. HVOTO
11. Severe comorbid cardiopulmonary diseases or extrahepatic malignancy

Where it's running

• Institute of Liver & Biliary Sciences (ILBS)
  New Delhi, National Capital Territory of Delhi, India Recruiting

Study contacts

• Study coordinator: Dr Gnana Kavitha, MD
• Email: kavuluj4444@gmail.com
• Phone: 01146300000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.