Determining the best oxytocin dose for cesarean delivery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to find the minimal effective dose of oxytocin infusion needed for laboring women undergoing cesarean delivery to ensure optimal uterine contraction and minimize postpartum hemorrhage. It employs a prospective, double-blinded design where the infusion dose is adjusted based on the previous patient's response. The goal is to establish the dose that achieves adequate uterine tone in 90% of patients. The study will be conducted at Mount Sinai Hospital in Toronto, Ontario.

Why it matters

Who can join: the full rules

Inclusion Criteria:

• All patients with induced or augmented labour undergoing cesarean delivery under neuraxial anesthesia (at least 3 hours of prior exposure to oxytocin during labour)

Exclusion Criteria:

* All patients who refuse to give written informed consent
* All patients who declare allergy or hypersensitivity to oxytocin
* A history of hypertension and/or severe cardiac disease(s)
* All patients who have contraindications for neuraxial anesthesia
* All patients who will be converted to general anesthesia intraoperatively
* All patients with placenta previa and multiple gestation

Where it's running

• Mount Sinai Hospital
  Toronto, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Mrinalini Balki, MD — Mount Sinai Hospital
• Study coordinator: Mrinalini Balki, MD
• Email: mrinalini.balki@uhn.ca
• Phone: 416-586-4800

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.