Determining safe levels to stop phototherapy for newborn jaundice

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates whether a lower threshold for discontinuing phototherapy can reduce the rates of rebound hyperbilirubinemia in term and late preterm neonates suffering from hemolytic disease of the newborn. Participants will be divided into two groups: one will stop phototherapy at a higher threshold, while the other will stop at a lower threshold. The study aims to compare the safety and effectiveness of these two approaches in managing neonatal jaundice. The intervention involves administering phototherapy based on established guidelines and monitoring bilirubin levels closely.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Healthy term and late-preterm neonates more than or equal 35 weeks gestation with hemolytic disease of newborn will be included. Enrolled infants should have evidence of hemolysis as defined by any of the following criteria:

1. positive DAT and blood group iso-immunization (ABO / RH incompatibility);and /or
2. HGB decline by 2g/dl within 24hour.

Exclusion Criteria:

* Major congenital abnormalities,
* Surgical problems,
* Direct hyperbilirubinemia
* Sepsis

Where it's running

• Madinah maternity and children's hospital
  Madinah, Saudi Arabia Recruiting

Study contacts

• Principal investigator: Fatimah S Alhazmi, MD — Ministry of Health, Saudi Arabia
• Study coordinator: Fatimah S Alhazmi, MD
• Email: f.alhazmi@hotmail.com
• Phone: 00 966 54 0564141

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Breath carbon monoxide measurement to help manage newborn jaundice.

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  Recruiting The Fourth Affiliated Hospital of Zhejiang University School of Medicine · Yiwu, Zhejiang · NCT07346976

• Using exhaled carbon monoxide to guide modified care for newborn hemolysis causing severe jaundice

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• High-intensity and cycled phototherapy for newborn jaundice

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  Recruiting at 2 sites Phase 2/3 Regionshospital Nordjylland · Aalborg and 1 other locations · NCT06702241

• Global registry for hemolytic disease of the fetus and newborn (HDFN)

  This project will follow pregnant people at risk for HDFN to see how often their fetuses or newborns develop anemia while receiving standard care.

  Recruiting at 16 sites Janssen Research & Development, LLC · Indianapolis, Indiana and 16 other locations · NCT07194070

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.