Detecting sepsis using blood fluorescence analysis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to develop a reagent-free blood fluorescence metabolite analyzer to detect sepsis at an early stage, before organ damage occurs. By utilizing a case-control method, the study will compare blood samples from healthy individuals, septic patients, and non-septic severe patients to identify changes in blood optical characteristics associated with inflammatory free radicals. The goal is to create a highly sensitive screening tool that can reduce the time to diagnosis and improve patient outcomes in sepsis management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Healthy control group: Individuals who are physically healthy with no underlying diseases and have not been hospitalized within the past two years. Recruitment for healthy volunteers will be conducted through notices and online media.
2. Sepsis Experimental Group: Patients with confirmed infections, having qSOFA ≥ 2 and SOFA ≥ 2, will be screened and confirmed by a physician to meet the inclusion criteria.
3. Non-septic Severe Control Group: Patients with suspected or confirmed infections, having a SOFA score of 1, will be screened and confirmed by a physician to meet the inclusion criteria.

Exclusion Criteria: minors, pregnant, individuals with mental illnesses, and other vulnerable groups.

Where it's running

• Ningbo Institute of Innovation for Combined Medicine and Engineering (NIIME), Ningbo Medical Center Lihuili Hospital, Ningbo University
  Ningbo, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Fei Guo, Dr.
• Email: lhlguofei@nbu.edu.cn
• Phone: 86 13646607121

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.