Detecting how well chemotherapy works in patients with metastatic nasopharyngeal carcinoma using blood tests.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to recruit 50 patients with metastatic nasopharyngeal carcinoma (mNPC) to evaluate their response to cisplatin-based chemotherapy by analyzing circulating tumor cells (CTCs) from their blood. The study will monitor changes in CTCs to predict treatment efficacy and assess patients' chemosensitivity. Participants must have measurable metastatic lesions and meet specific health criteria to ensure their safety during the study. The findings could provide valuable insights into personalized treatment approaches for mNPC patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* NPC patients with distant metastasis after 3 months of primary radiotherapy, and not suitable for local treatment
* At least having one measurable metastatic lesion
* All genders，range from 18～70 years old
* ECOG score 0 \~ 1
* Expected survival time ≥ 3 months
* White blood cell(WBC) count ≥ 3×109/L, neutrophile granulocyte(NE) count ≥ 1.5×109/L, hemoglobin(HGB) ≥ 90g/L, platelet(PLT) count ≥ 100×109/L
* Alanine aminotransferase (ALT) or aspartate aminotransferase(AST) \< 2.5×upper limit of normal(ULN), bilirubin(BUN) or creatinine(CRE) \< 1.5×ULN, alanine aminotransferase (CCR) ≥ 60ml/min
* Inform consent form

Exclusion Criteria:

* Have or are suffering from other malignant tumors;
* Participating in other clinical trials;
* Drug or alcohol addition;
* Do not have full capacity for civil acts;
* Mental disorder;
* Pregnancy or lactation;
* Severe complication, eg, uncontrolled hypertension.

Where it's running

• Cancer Center, Sun Yat-sen University
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Principal investigator: Chong Zhao, M.D — Sun Yat-sen University
• Study coordinator: Jingjing Miao, M.D
• Email: miaojingjing90@163.com
• Phone: 86-13631355201

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.