Detecting heart muscle injury during below-knee leg surgery with peripheral nerve block
Evaluation of Perioperative Myocardial Injury in Patients Undergoing Below-knee Lower Extremity Surgery With Peripheral Nerve Block
This will test whether measuring high‑sensitive troponin I during and after below‑knee leg surgery can detect heart muscle damage in adults receiving peripheral nerve blocks.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 54 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Ankara City Hospital Bilkent Academic / other |
| Locations | 1 site (Ankara) |
| Trial ID | NCT07241572 on ClinicalTrials.gov |
What this trial studies
This is an observational study that measures high‑sensitive troponin I levels before surgery, during the operation, and at 24 and 48 hours after below‑knee lower extremity procedures performed with peripheral nerve blocks. Clinical and anesthetic details (type and dose of local anesthetic, intraoperative blood pressure, heart rate changes, inotrope use, fluids, urine output, and operation time) will be recorded to look for factors associated with troponin changes. The primary focus is whether perioperative troponin elevations indicate myocardial injury in this surgical setting; secondary analyses will explore which perioperative parameters correlate with troponin rise. All participants will have routine preoperative labs and hs‑troponin I measured as part of the monitoring protocol.
Who should consider this trial
Good fit: Adults aged 18 and older who are undergoing below‑knee lower extremity surgery with peripheral nerve block, are able to give informed consent, and meet ASA I–IV criteria are ideal candidates.
Not a fit: Patients who cannot receive regional anesthesia, who refuse participation, or whose care is not managed at the study site are not eligible and therefore will not benefit from this protocol.
Why it matters
Potential benefit: If successful, this approach could identify otherwise unrecognized perioperative heart injury earlier in patients having below‑knee surgery, allowing clinicians to address cardiac risk sooner.
How similar studies have performed: High‑sensitive troponin is an established marker for perioperative myocardial injury in other surgical populations, but its routine monitoring during below‑knee procedures with peripheral nerve blocks is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients over 18 years of age * Patients undergoing below-knee lower extremity surgery * Patients with ASA classifications I, II, III, and IV * Patients who have consented before the procedure * Patients who are literate and able to give consent Exclusion Criteria: * Patients in whom regional anesthesia is contraindicated * Patients who refuse to participate in the study
Where this trial is running
Ankara
- Ankara Bilkent City Hospital — Ankara, Turkey (Türkiye) (Recruiting)
Study contacts
- Principal investigator: Harun Zengin — harunzengin71@gmail.com
- Study coordinator: Harun Zengin
- Email: harunzengin71@gmail.com
- Phone: 05422358195
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.