Detecting early Alzheimer's disease using MRI technology

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to improve the early diagnosis of Alzheimer's disease (AD) by utilizing a novel MRI technique called glucose Chemical Exchange Saturation Transfer (glucoCEST). Unlike traditional methods that rely on radioactive tracers and PET imaging, glucoCEST MRI offers a non-invasive and repeatable approach to assess cerebral glucose levels in patients. The study will include individuals aged 65 and older, both diagnosed with AD and healthy controls, to compare glucose metabolism and cognitive function. By identifying early signs of AD, the study seeks to facilitate timely intervention and management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Development phase:

Controls (development group) must:

* be \> 18 years
* consent to the study
* not report problems with memory.

Clinical phase

Patients must:

* be ≥ 65 years,
* able to provide informed consent to the study
* have been clinically diagnosed with AD by the mental health team.

Controls must:

* be ≥ 65 years
* able to provide consent to the study
* have a normal score in the ADAS-cog test and the Mini Mental State Examination test (MMSE)
* not report problems with memory.

Exclusion Criteria:

Subjects will not be considered if they:

* have a history of diabetes,
* have history of a major stroke (mini-stroke/Transient Ischaemic Attacks or lacunar stroke are acceptable),
* have contra-indications to MRI scanning such as implantable cardiac devices
* have family history in AD, to exclude possible gene mutations associated with AD
* have advanced AD who lack the capacity to consent.
* Are pregnant (for developmental phase)
* are unable to read or speak English

Where it's running

• University of Aberdeen
  Aberdeen, United Kingdom Recruiting

Study contacts

• Study coordinator: Gordon Waiter, PhD
• Email: g.waiter@abdn.ac.uk
• Phone: +44 (0)1224 438356

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.