Clinical trial Recruiting at 1 site Observational Ages 18 to 85

Depression and mild cognitive problems in adults hospitalized with chronic heart failure

Official title: Prevalence of Depressive Symptoms and Cognitive Impairment and Their Association With Worse Outcomes in a Cohort of Hospitalized Patients With Chronic Heart Failure

Run by Lithuanian University of Health Sciences · NCT07284446 · Data updated 2026-11-12

See if depressive symptoms and mild cognitive impairment lead to worse outcomes for adults (18–85) hospitalized with chronic heart failure.

Quick facts

Study typeObservational
Ages18 Years to 85 Years
SexAll
Enrollment300 (estimated)
SponsorLithuanian University of Health Sciences
Academic / other
Locations1 site (Kaunas)
StatusRecruiting
StartedDecember 2, 2025
Main results expectedDecember 2, 2028
Study endsDecember 2, 2028
Registry record updatedDecember 16, 2025
Trial IDNCT07284446 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults 18–85 hospitalized primarily for a chronic heart failure exacerbation who are clinically stable, able to consent, not severely cognitively impaired, have a transthoracic echocardiogram available, and are expected to stay at least 96 hours.

Probably not a fit

Patients admitted for acute heart failure, those with very short stays (<96 hours), severe visual or cognitive impairments preventing testing, or without recent/planned TTE are unlikely to receive benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, prospective observational cohort at LSMU Kaunas Hospital will enroll adults aged 18–85 admitted primarily for chronic heart failure exacerbation. Clinically stable participants will complete questionnaires and brief cognitive testing to measure depressive symptoms and mild cognitive impairment, with exclusions for severe cognitive or visual impairment and short hospital stays. Investigators will link these baseline measures to clinical outcomes such as rehospitalizations and mortality to determine associations. The study aims to clarify prevalence and prognostic importance of mental health and cognitive symptoms in routine CHF inpatient care in the Kaunas region.

Why it matters

Potential benefit: If successful, the study could help identify hospitalized CHF patients at higher risk of rehospitalization or death so clinicians can target supportive care and follow-up.

How similar studies have gone: Prior studies have linked depression and cognitive impairment to worse outcomes in heart failure, so this approach builds on existing evidence though it is not yet routinely integrated into care.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* patient hospitalized primarily for CHF exacerbation;
* clinically stable, able to provide informed consent;
* do not have severe cognitive impairment that would preclude valid questionnaire administration.

Exclusion Criteria:

* hospitalization for acute heart failure;
* total length of hospital stay \<96 hours;
* absence of transthoracic echocardiography (TTE) within the last 12 months and no TTE planned;
* severe visual impairment preventing completion of the visual part of the Montreal Cognitive Assessment;
* refusal to participate.

Where it's running

  • Kaunas Hospital of the Lithuanian University of Health Sciences
    Kaunas, Lithuania
    Recruiting

Study contacts

  • Principal investigator: Andrius Ališauskas, MD, PhD — Lithuanian University of Health Sciences
  • Study coordinator: Andrius Ališauskas, MD, PhD
  • Email: andrius.alisauskas@lsmu.lt
  • Phone: +37060379771

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.