Deep versus moderate muscle relaxation during hysterectomy
The Effect of Deep Versus Moderate Neuromuscular Blocking on Patients Undergoing Open Hysterectomy
This study will test whether using deep versus moderate muscle relaxation during elective hysterectomy changes surgical conditions, opioid requirements, and blood inflammation markers for women having the operation.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 88 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | Female |
| Sponsor | Menoufia University Academic / other |
| Locations | 1 site (Menoufia, Eg.mn) |
| Trial ID | NCT07485517 on ClinicalTrials.gov |
What this trial studies
Women scheduled for elective hysterectomy at a single center will receive either deep or moderate neuromuscular blockade during their operation, and perioperative management will follow standard protocols. Investigators will compare changes in serum inflammatory cytokines from preoperative baseline and measure total intraoperative fentanyl and postoperative morphine use. Secondary outcomes include postoperative pain scores and surgeons' subjective ratings of the surgical field. Eligibility is limited to ASA I–II patients with BMI under 35, excluding those with neuromuscular disorders, severe anemia, autoimmune disease, or on immunosuppressants.
Who should consider this trial
Good fit: Women scheduled for elective hysterectomy who are ASA I–II with BMI <35 and without neuromuscular, autoimmune, or uncontrolled medical conditions are the intended participants.
Not a fit: Patients with neuromuscular disorders, severe anemia, autoimmune disease, or on immunosuppressant therapy are excluded and would not be expected to benefit from this protocol.
Why it matters
Potential benefit: If successful, using deeper neuromuscular blockade could improve surgical conditions, reduce opioid consumption, and lower postoperative inflammatory markers after hysterectomy.
How similar studies have performed: Prior work in laparoscopic surgery has shown that deep neuromuscular blockade can improve operating conditions and sometimes reduce opioid needs, but its specific effects on inflammatory cytokines in hysterectomy are less well established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women who will be admitted to undergo elective hysterectomy ,-ASA grade I or II, * Body mass index (BMI) of \<35 kg/m2 Exclusion Criteria: hemoglobin concentration of ≤7 gm%, * the presence of neuromuscular disorders * uncontrolled medical diseases * autoimmune diseases, maintenance on immunosuppressant therapy for any indication * refusal to sign the written consent
Where this trial is running
Menoufia, Eg.mn
- Faculty of Medicine Menoufia University — Menoufia, Eg.mn, Egypt (Recruiting)
Study contacts
- Principal investigator: Rabab M Habeeb — Faculty of Medicine Menoufia University
- Study coordinator: Rabab Habeeb, MD
- Email: rabab_habeeb@med.menofia.edu.eg
- Phone: +201001970973
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.