Deep versus moderate muscle relaxation during hysterectomy
Official title: The Effect of Deep Versus Moderate Neuromuscular Blocking on Patients Undergoing Open Hysterectomy
Run by Menoufia University · NCT07485517 · Data updated 2026-11-12
This study will test whether using deep versus moderate muscle relaxation during elective hysterectomy changes surgical conditions, opioid requirements, and blood inflammation markers for women having the operation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | Women only |
| Enrollment | 88 (estimated) |
| Sponsor | Menoufia University Academic / other |
| Locations | 1 site (Menoufia, Eg.mn) |
| Status | Recruiting |
| Started | June 1, 2026 |
| Main results expected | December 1, 2026 |
| Study ends | December 30, 2026 |
| Registry record updated | August 13, 2026 |
| Trial ID | NCT07485517 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women scheduled for elective hysterectomy who are ASA I–II with BMI <35 and without neuromuscular, autoimmune, or uncontrolled medical conditions are the intended participants.
✕Probably not a fit
Patients with neuromuscular disorders, severe anemia, autoimmune disease, or on immunosuppressant therapy are excluded and would not be expected to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Women scheduled for elective hysterectomy at a single center will receive either deep or moderate neuromuscular blockade during their operation, and perioperative management will follow standard protocols. Investigators will compare changes in serum inflammatory cytokines from preoperative baseline and measure total intraoperative fentanyl and postoperative morphine use. Secondary outcomes include postoperative pain scores and surgeons' subjective ratings of the surgical field. Eligibility is limited to ASA I–II patients with BMI under 35, excluding those with neuromuscular disorders, severe anemia, autoimmune disease, or on immunosuppressants.
Why it matters
Potential benefit: If successful, using deeper neuromuscular blockade could improve surgical conditions, reduce opioid consumption, and lower postoperative inflammatory markers after hysterectomy.
How similar studies have gone: Prior work in laparoscopic surgery has shown that deep neuromuscular blockade can improve operating conditions and sometimes reduce opioid needs, but its specific effects on inflammatory cytokines in hysterectomy are less well established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women who will be admitted to undergo elective hysterectomy ,-ASA grade I or II, * Body mass index (BMI) of \<35 kg/m2 Exclusion Criteria: hemoglobin concentration of ≤7 gm%, * the presence of neuromuscular disorders * uncontrolled medical diseases * autoimmune diseases, maintenance on immunosuppressant therapy for any indication * refusal to sign the written consent
Where it's running
-
Faculty of Medicine Menoufia University
Menoufia, Eg.mn, Egypt Recruiting
Study contacts
- Principal investigator: Rabab M Habeeb — Faculty of Medicine Menoufia University
- Study coordinator: Rabab Habeeb, MD
- Email: rabab_habeeb@med.menofia.edu.eg
- Phone: +201001970973
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.