Deep Marginal Elevation: effects on gum and bone health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a longitudinal clinical study of adults needing Class II restorations in which Deep Marginal Elevation (DME) will be performed and patients followed over time. Gingival crevicular fluid will be collected to measure inflammatory markers (e.g., IL-1β, TNF-α, MMP-8, PGE2, CRP) and microbiological profiles. Bitewing radiographs will be used to monitor crestal bone level and bone density changes, using the healthy contralateral tooth as an internal control. Participants with systemic disease, active periodontal infection, recent anti-inflammatory use, pregnancy, or lactation are excluded and follow-up visits are required to track outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged 18-60 years.
* Diagnosed with Class II dental caries requiring restoration.
* Presence of a healthy contralateral tooth (control side).
* Willingness to participate and comply with follow-up visits.

Exclusion Criteria:

* Systemic diseases (e.g., diabetes, autoimmune disorders).
* Periodontal disease or active infection.
* Use of anti-inflammatory medications within the last month.
* Pregnancy or lactation.

Where it's running

• Tanta University
  Tanta, El-Gharbia, Egypt Recruiting

Study contacts

• Study coordinator: Mohamed O Elboraey, MD
• Email: mohamedomarelboraey@gmail.com
• Phone: 00201062250015

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.