Deep dental cleaning to see if treating gum disease helps kidney health in people with type 2 diabetes
Outcomes of Non-surgical Periodontal Therapy on Urea and Creatinine Levels in Type-2 Diabetes Mellitus Patients
This study will try non-surgical deep dental cleaning (scaling and root planing) to see if it improves kidney blood tests in adults with uncontrolled type 2 diabetes and moderate-to-severe gum disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 46 (estimated) |
| Ages | 30 Years to 65 Years |
| Sex | All |
| Sponsor | Dow University of Health Sciences Academic / other |
| Locations | 1 site (Karachi, Sindh) |
| Trial ID | NCT07256613 on ClinicalTrials.gov |
What this trial studies
This interventional study enrolls adults (30–65 years) with uncontrolled type 2 diabetes (HbA1c ≥ 7%) and moderate-to-severe periodontitis who have preserved kidney function (eGFR ≥ 60 mL/min/1.73 m²). Participants will receive non-surgical periodontal therapy (scaling and root planing) and be followed with blood tests for renal biomarkers including urea, serum creatinine, and estimated glomerular filtration rate (eGFR). The design compares renal biomarker changes after periodontal treatment to characterize any downstream effects on kidney function. The trial aims to provide preliminary data on whether reducing periodontal inflammation can influence markers linked to diabetic nephropathy.
Who should consider this trial
Good fit: Ideal candidates are adults 30–65 years old with type 2 diabetes for at least one year, HbA1c ≥ 7%, moderate-to-severe periodontitis, eGFR ≥ 60 mL/min/1.73 m², and the ability to give informed consent.
Not a fit: Patients with advanced kidney disease (eGFR < 60), well-controlled diabetes (HbA1c < 7%), recent use of systemic anti-inflammatory drugs or antibiotics, pregnant or breastfeeding women, or those unable to attend the Karachi site are unlikely to benefit from or be eligible for this protocol.
Why it matters
Potential benefit: If successful, periodontal treatment could help improve or slow decline in early kidney function markers in people with uncontrolled type 2 diabetes.
How similar studies have performed: Previous studies have shown periodontal therapy can improve blood sugar control, but evidence that it improves kidney function is limited and remains largely unproven.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Adults between 30 and 65 years of age. Men and women previously diagnosed with type 2 diabetes mellitus for at least one year. Participants with uncontrolled diabetes, defined as HbA1c ≥ 7%. Presence of moderate to severe gum disease (Stage II or Stage III periodontitis) as determined by a dental examination. Estimated glomerular filtration rate (eGFR) of 60 mL/min/1.73 m² or higher. Willing and able to provide written informed consent. Exclusion Criteria: Critically ill individuals or those unable to communicate effectively. Pregnant or breastfeeding women. Women currently using hormone replacement therapy or oral contraceptives within the past six months. Individuals taking steroidal, nonsteroidal anti-inflammatory drugs (NSAIDs), or other anti-inflammatory medications within the past three months (except low-dose aspirin up to 75 mg daily). Participants with a recent history of major blood loss, trauma, or gastrointestinal bleeding. Use of antibiotics within the last month. History of fever or vomiting lasting more than one week within the last month. Regular tobacco or alcohol users. Individuals with any other chronic disease or condition that could interfere with study outcomes. Individuals unwilling or unable to comply with study procedures or follow-up visits.
Where this trial is running
Karachi, Sindh
- Dow University of Health Scinces — Karachi, Sindh, Pakistan (Recruiting)
Study contacts
- Study coordinator: Muhammad Ather Khan, BDS
- Email: ather.khan@duhs.edu.pk
- Phone: +92-333-2685579
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.