Deep cleaning (PMPR) plus chlorhexidine mouthwash for gums and blood vessel health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Thirty adults with clinically confirmed gingivitis or stage 1–2 periodontitis will receive standard professional mechanical plaque removal (PMPR). After PMPR, participants will use either 0.2% chlorhexidine mouthwash or a placebo mouthwash and be followed for changes in salivary and acquired enamel pellicle proteins, oral microbiome composition, and nitrate-reducing bacteria activity. Vascular outcomes such as endothelial function and arterial stiffness will be measured alongside oral endpoints to explore oral-systemic links. The study compares pre- and post-treatment measures to see if adjunctive chlorhexidine alters beneficial oral bacteria or vascular health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants must have a minimum of 2 natural teeth in each sextant (at least 12 teeth overall).
* Individuals with clinically diagnosed gingivitis and/or early periodontitis (stage 1 and 2)
* Must not have undergone periodontal maintenance therapy (PMPR) within the last 6 months.
* Must not currently be wearing orthodontic appliances, due to their effect on oral microbiota and plaque composition.
* Must not be using removable orthodontic appliances, as they increase plaque accumulation.
* Must not have taken any antibiotic treatments within the last 3 months.
* Must be able to provide written informed consent.
* Individuals with dental erosion or caries will still be included but matched during the baseline visit.

Exclusion Criteria:

* Individuals under regular medication within one month of the study start date for any medical condition (such as hypertension and/or diabetes)
* Pregnant or breastfeeding individuals.
* Individuals requiring an interpreter or who are non-English speakers.
* Individuals unable to provide written informed consent.
* Individuals participating in another ongoing clinical study (other than observational studies) within 3 months prior to or during this study.
* Individuals who have used mouthwash or tongue scrapers in the last 6 weeks.
* Individuals who consume 20 or more cigarettes per day.
* Individuals who consume more than 5 alcoholic drinks per day.

Where it's running

• University of Portsmouth
  Portsmouth, Hampshire, United Kingdom Recruiting

Study contacts

• Study coordinator: Mahdi Mutahar, PhD
• Email: mahdi.mutahar@port.ac.uk
• Phone: 02392845528

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.