Database of stroke patients treated with thrombectomy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to create a clinical and advanced imaging database for acute ischemic stroke patients who have undergone mechanical thrombectomy due to large vessel occlusion in the anterior circulation within 24 hours of stroke onset. It will involve a multi-center, prospective registry cohort study across various stroke centers in China, enrolling approximately 1600 patients. The study will also analyze predictors and mechanisms of futile recanalization after the procedure, utilizing both prospective and retrospective data.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Older than 18 years;
* Perfusion imaging completed including CTA+CTP or MRA+PWI+DWI before thrombectomy
* Large vessel occlusion of cerebral anterior circulation (ICA, MCA-M1 or MCA-M2) confirmed by CTA or MRA, planned to receive or received stenting or aspiration thrombectomy
* Time intervals ≤ 24 hours from stroke onset to groin puncture.(fulfilled the inclusion of DAWN or DEFUSE 3 trial if the time intervals from stroke onset to groin puncture was ≥6 hours)
* mRS score ≤2 before admission
* Informed consent obtained for longitudinal enrolled patients, waived of consent for retrospectively included cases

Exclusion Criteria:

* Had a history of infective disease, immunity disease, radiotherapy at head or neck, carotid dissection or other carotid disease.
* Unable to receive CT or MR scan due to heart failure, cardiac pacemaker, metal implants or claustrophobia, etc.
* Unable to be injected with contrast agent due to allergy, renal dysfunction, etc.
* Unlikely to adhere to the study protocol or follow-up ( life expectancy ≤ 3 months)
* Already participated in other drug trials

Where it's running

• Yunyun Xiong
  Beijing, China Recruiting

Study contacts

• Principal investigator: Yunyun Xiong, MD, PhD — Beijing Tiantan Hospital
• Study coordinator: Yunyun Xiong, MD, PhD
• Email: xiongyunyun@bjtth.org
• Phone: 00861059975213

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals

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• Web-based therapy using action observation and mirror therapy for arm weakness after stroke

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• Remote Ischaemic Conditioning for Fatigue After Stroke 2

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• Dual-task balance training plus computer-based cognitive training after stroke

  In adults who recently had a stroke, the study tests whether adding computerized cognitive exercises to balance training improves balance and other recovery outcomes.

  Recruiting Matia Foundation · San Sebastián, GUIPUZCOA · NCT07913620

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.