Daily protein plus weekly resistance training to prevent muscle loss after bariatric surgery
Official title: Effectiveness of Protein SupplementatIon Combined With Resistance Exercise Training to Counteract Disproportional Fat-Free Mass Loss Following Metabolic-Bariatric Surgery: The ENRICHED Study
Run by Radboud University Medical Center · NCT07156552 · Data updated 2026-11-12
The trial will test whether taking a daily protein supplement and doing one supervised resistance workout each week helps people having bariatric surgery keep their muscle mass.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | Radboud University Medical Center Academic / other |
| Locations | 2 sites (Amsterdam and 1 other locations) |
| Status | Recruiting |
| Started | June 20, 2025 |
| Main results expected | May 30, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | August 11, 2026 |
| Trial ID | NCT07156552 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults scheduled for Roux-en-Y gastric bypass or sleeve gastrectomy who are enrolled in the Nederlandse Obesitas Kliniek (NOK) care program and able to follow supplement and weekly supervised exercise procedures.
✕Probably not a fit
Patients with milk-protein allergy or lactose intolerance, diagnosed renal insufficiency, or intestinal diseases that impair protein absorption — and those unable to attend weekly supervised sessions — may not benefit or may be excluded.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized interventional study will compare usual postoperative care to usual care plus daily protein supplementation and one supervised resistance training session per week in patients undergoing Roux-en-Y gastric bypass or sleeve gastrectomy. Participants treated at participating centers will be randomly assigned to the two groups and followed for changes in fat-free mass and related outcomes. The study targets prevention of excessive muscle loss, a complication reported in about 20% of bariatric patients. While resistance training and protein intake are each known to support muscle mass, the combined effect in the bariatric population will be measured.
Why it matters
Potential benefit: If successful, the approach could help patients retain muscle mass and strength after bariatric surgery, improving recovery and long-term function.
How similar studies have gone: Previous studies show resistance training and increased protein intake each help preserve or build muscle, but randomized data on the combined intervention specifically after bariatric surgery are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * A scheduled metabolic-bariatric surgery (i.e. RYGB or Sleeve Gastrectomy) * Participation in the NOK care program * Able to understand and perform the study procedures Exclusion Criteria: * Allergic or sensitive for milk proteins, or lactose intolerant * Diagnosed renal insufficiency * Diagnosed intestinal diseases influencing the uptake of protein (i.e. active inflammatory bowel disease
Where it's running
-
Nederlandse Obesitas Kliniek
Nieuwegein, Netherlands Recruiting -
Nederlandse Obesitas Kliniek
Amsterdam, Netherlands Not yet recruiting
Study contacts
- Principal investigator: M. T.E. Hopman, Prof. Dr. — Radboud University Medical Center
- Study coordinator: J. H.M. Karregat, Dr.
- Email: jan.karregat@radboudumc.nl
- Phone: +31653461919
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
15-year outcomes after sleeve gastrectomy in France
This study looks at how people who had sleeve gastrectomy have fared over 15 years to see long-term weight changes and health effects.
-
Mother and baby health after bariatric surgery in pregnancy
This study follows pregnant women who have had bariatric surgery and those who have not to see how nutrition, pregnancy health, and baby outcomes compare.
-
Understanding glucagon and sugar metabolism after meals in people with and without PBH after weight-loss surgery
This study tests how glucagon and post-meal glucose handling differ between people who have post-bariatric surgery hypoglycemia and those who don’t.
-
Collagen Supplements After Sleeve Gastrectomy
This observational study looks to see if taking collagen-containing supplements after sleeve gastrectomy affects muscle mass, body composition, and body image in adults who had bariatric surgery.
-
Postoperative nausea, vomiting and pain after bariatric surgery in Sweden
This study looks at how often people have nausea, vomiting, and pain after bariatric surgery in Sweden and whether anesthesia type or regional blocks affect those outcomes.
-
Hormonal changes after two bariatric surgeries in super-obese people
This study tests whether sleeve gastrectomy with duodenojejunal bypass leads to different hormone responses and less post-meal hypoglycemia than Roux-en-Y gastric bypass in people with extreme obesity.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.