Daily nonalcoholic red-wine polyphenol drink to support thinking and mobility in early elderly adults
Polyphenols From Nonalcoholic Red Wine and Healthy Aging: an Opportunity to Understand Diet Modulation of the Aging Process From a Multidimensional Perspective
This 9-month test will see if drinking a daily nonalcoholic red-wine beverage rich in polyphenols improves cognition and muscle function in people aged 60–74.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 72 (estimated) |
| Ages | 60 Years to 74 Years |
| Sex | All |
| Sponsor | University Rovira i Virgili Academic / other |
| Locations | 3 sites (Logroño, Spain and 2 other locations) |
| Trial ID | NCT06871384 on ClinicalTrials.gov |
What this trial studies
This interventional, two-arm trial will randomize 72 community-dwelling volunteers aged 60–74 to either a nonalcoholic red-wine beverage or drinking water for nine months, with 36 participants per arm. Participants will attend 11 scheduled visits including baseline, periodic telephone check-ins, and fasting blood draws at key visits; objective measures include NMR body composition, optional muscle biopsy, and isokinetic muscle testing alongside questionnaires for activity, mood, and quality of life. The intervention targets modulation of the gut microbiota and antioxidant/anti-inflammatory effects of polyphenols to influence the gut–muscle and gut–brain axes. Outcomes will compare changes in cognitive and locomotor measures between the two groups over the intervention period.
Who should consider this trial
Good fit: Ideal candidates are community-dwelling men or women aged 60–74 who can tolerate nonalcoholic red wine, are free of diabetes, active chronic disease, severe sarcopenia, or cognitive impairment, and can commit to study visits in Spain.
Not a fit: People with diabetes, anemia, active intestinal disease, severe sarcopenia, cognitive impairment, chronic alcoholism, or regular alcoholic red-wine consumers unwilling to switch are excluded and unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, the intervention could help slow age-related cognitive decline and improve muscle strength, supporting greater independence in older adults.
How similar studies have performed: Observational studies and small trials suggest resveratrol and other dietary polyphenols can benefit cognition and muscle via gut–brain and gut–muscle pathways, but randomized evidence in older adults remains limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1\. Men or women between 60-74 years old; Sensory tolerance to red wine; Written informed consent provided before the initial screening visit. Exclusion Criteria: 1. Men or women \>75 years old, 2. Hypoglucaemiant treatment or type 1 and type 2 diabetes mellitus diagnosed 3. Anaemia (hemoglobin ≤13 g/dL in men and ≤12 g/dL in women) 4. Subjects diagnosed of intestinal disorders such as chron disease, colitis ulcerous, and irritable bowel syndrome 5. To present a clinical active chronic disease 6. To present severe sarcopenia 7. To present cognitive impairment (MMSE ≤ 24 or clinical diagnosis of mild cognitive impairment or dementia) 8. Dietary allergies to: Mediterranean foods (eg, nuts), sulphytes or nitrates 9. Use of antioxidants supplements 10. Regular consumers of red wine who do not agree to change the consumption of red wine with alcohol to nonalcholized wine during the intervention 11. Chronic alcoholism 12. Current or past participation in a clinical trial or consumption of a research product in the 30 days prior to inclusion in the study 13. Failure to follow the study guidelines. For participation in the muscle biopsy, additional exclusion criteria included: Use of prescription anti-platelet medication; Prescription anticoagulant use (or antiaggregant, or acenocoumarol; Conditions which would reduce healing; or known allergy to lidocaine.
Where this trial is running
Logroño, Spain and 2 other locations
- Instituto de Ciencias de la Vid y del Vino-ICVV (Consejo Superior de Investigaciones Científicas-CSIC, Universidad de La Rioja, Gobierno de La Rioja) — Logroño, Spain, Spain (Active_not_recruiting)
- Lyfestyle, Microbiota and Health Unit, Health Sciences Faculty, University of La Rioja — Logroño, Spain, Spain (Active_not_recruiting)
- Universitat Rovira i Virgili, Facultat de Medicina i Ciències de la Salut, Functional Nutrition, Oxidation, and Cardiovascular Diseases Group (NFOC-Salut) — Reus, Spain, Spain (Recruiting)
Study contacts
- Principal investigator: Rosa Solà Alberich, Professor — Universitat Rovira i Virgili, Facultat de Medicina i Ciències de la Salut, NFOC-Salut group, 43201 Reus, Spain Institut Investigació Sanitària Pere i Virgili (ISPV), 43204, Reus, Spain Hospital Universitari Sant Joan de Reus, 43204, Reus, Spain
- Study coordinator: Rosa Solà Alberich, Professor
- Email: rosa.sola@urv.cat
- Phone: +34 977 759 369
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.