Customizable antibiotic stewardship for French nursing homes
Official title: Evaluation of A Customizable Antibiotic Stewardship Program Based on a Comprehensive Assessment of Organizations and Health Professionals' Attitudes, and Tailored to French Nursing Homes' Needs
Run by University of Lorraine · NCT07246382 · Data updated 2026-11-12
This study tests a customizable antibiotic stewardship program to see if it improves antimicrobial use in French nursing homes.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 66 (estimated) |
| Sponsor | University of Lorraine Academic / other |
| Locations | 2 sites (Nantes and 1 other locations) |
| Status | Recruiting |
| Started | April 14, 2026 |
| Main results expected | July 14, 2027 |
| Study ends | July 14, 2028 |
| Registry record updated | October 5, 2026 |
| Trial ID | NCT07246382 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are nursing homes located in the participating regions and residents aged 18 or older who have lived in the facility during the study period, along with healthcare professionals working there.
✕Probably not a fit
Residents or facilities without access to the intervention or with data limitations may not experience benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial examines an antimicrobial stewardship program (the ORANEAT program) implemented in nursing homes in two French regions. It aims to address antimicrobial resistance by promoting responsible antimicrobial use within complex care settings. The study considers how local context may affect implementation and transferability. Eligible sites are nursing homes in participating regions, with both residents and healthcare professionals evaluated on predefined outcomes. Lead institutions include the University of Lorraine and collaborating French research centers.
Why it matters
Potential benefit: If successful, the program could reduce inappropriate antibiotic use and curb resistance in nursing homes.
How similar studies have gone: Previous AMS programs in hospitals and nursing homes showed variable results, highlighting the importance of context-specific implementation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Nursing homes Inclusion criteria: • Nursing home located in one of the geographical areas participating in the study in two French regions (i.e., geographical areas covered by experts in antibiotic stewardship and/or in infection prevention and control who agreed to participate in the study) Exclusion criteria: * Nursing home with a pharmacy for internal use * Participation to the pilot study * Data from the Health Insurance reimbursement database (Système national des données de santé) not available on the study period * Refusal of the nursing director to participate in the study (for Arm 1 only) Residents (Outcomes 1 to 4 and outcome 12) Inclusion criteria: • Resident aged 18 or more who had lived in one of the participating nursing homes during the study period. Exclusion criteria: / Healthcare professionals (Outcomes 11, 13 and 15) Inclusion criteria: • Healthcare professionals aged 18 or more working in one of the participating nursing homes from Arm 1 (including healthcare professionals who provide services to or collaborate with the nursing home even if they are not on-site, e.g., private general practitioners, community pharmacists, microbiologists, and professionals responsible for the implementation support). Exclusion criteria: • Refusal to complete the self-administered questionnaires or to participate in qualitative investigations.
Where it's running
-
CPias PdL (for the Pays de la Loire region)
Nantes, France Recruiting -
CIC-EC (for the Grand Est region)
Vandœuvre-lès-Nancy, France Recruiting
Study contacts
- Principal investigator: Nelly AGRINIER, Professor — Université de Lorraine, Inserm, INSPIIRE, F-54000 Nancy, France; CHRU-Nancy, Inserm, Université de Lorraine, CIC, Epidémiologie clinique, Nancy, France
- Study coordinator: Mélanie BEGUINET
- Email: M.BEGUINET@chru-nancy.fr
- Phone: +333 83 15 34 79
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Using integron tests to guide first-line antibiotics for non-severe UTI in adults
This trial tests whether detecting integrons in urine can help doctors choose appropriate antibiotics for adults with non-severe urinary tract infections who had a resistant gram-negative infection in the past.
-
Assessing treatments for difficult-to-treat Pseudomonas infections
This study is testing different antibiotic treatments for tough Pseudomonas infections to see which ones work best for patients needing intravenous therapy.
-
Understanding addiction and trauma among young immigrants in France
This study looks at how trauma and substance use affect the mental health of young immigrants living in transitional housing in France to help create better support programs for them.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.