Assessing treatments for difficult-to-treat Pseudomonas infections

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The ADDICT study aims to evaluate the clinical efficacy of various antimicrobial therapies for infections caused by difficult-to-treat Pseudomonas aeruginosa. This prospective, multicenter cohort study will include patients requiring intravenous therapy for these infections, comparing newer beta-lactam/beta-lactamase inhibitor combinations and cefiderocol against older agents like aminoglycosides and colistin. The study will also investigate the emergence of drug resistance and the associated adverse events. By gathering multicenter data, the study seeks to provide insights into the real-life effectiveness of these treatment options.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All patients aged 18 or over and requiring intravenous definite antimicrobial therapy for a DTR P. aeruginosa infection

Exclusion Criteria:

* Cystic fibrosis
* P. aeruginosa DTR colonization or P. aeruginosa DTR infection not requiring definitive intravenous antibiotic therapy
* Protected person (under guardianship or curatorship)
* Persons under court protection
* Persons deprived of liberty
* Opposition expressed for participation in the study

Where it's running

• CHD Vendée
  La Roche-sur-Yon, France Recruiting
• CHRU Nancy
  Nancy, France Recruiting
• Centre Hospitalier Universitaire d'Orléans
  Orléans, France Recruiting
• Hopital Bichat
  Paris, France Recruiting
• CHU Amiens
  Amiens, France Not yet recruiting
• CH Argenteuil
  Argenteuil, France Not yet recruiting

Study contacts

• Principal investigator: Francois BARBIER, Professor — Centre Hospitalier Universitaire d'Orléans
• Study coordinator: FRANCOIS BARBIER, Professor
• Email: francois.barbier@chu-orleans.fr
• Phone: +33238229939

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.