CT biomarkers for classifying and predicting bronchiectasis outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will collect high-resolution chest CT scans and clinical data from adults with CT-confirmed bronchiectasis at Wuhan Union Hospital. Investigators will analyze imaging features such as emphysema, mucus plugs, dendritic signs, and adjacent parenchymal changes and relate them to clinical severity, infection risk, and disease progression during follow-up. Patients with major comorbid respiratory diseases, prior pulmonary surgery, traction bronchiectasis from fibrosis, or serious organ dysfunction are excluded to focus on non-traction bronchiectasis. The aim is to derive CT-based biomarkers that improve classification and prognostic stratification to support more personalized care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years and above;
* Can cooperate with CT scan;
* Bronchiectasis confirmed by high-resolution computed tomography of the lungs;
* Can provide written informed consent

Exclusion Criteria:

* Pulmonary surgery;
* Patients with lung cancer, asthma and other respiratory diseases;
* Tractive bronchiectasis caused by pulmonary fibrosis;
* Patients with malignant tumors or serious dysfunction of the heart, brain, kidney and other important systems can not cooperate with the completion of this study；
* Lack of important clinical information.

Where it's running

• Wuhan Union Hospital
  Wuhan, Hubei, China Recruiting

Study contacts

• Principal investigator: xiaorong Wang — Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
• Study coordinator: xiaorong Wang
• Email: rong-100@163.com
• Phone: 18627195231

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Chronic Respiratory Disease Participant Engagement

  This study tests whether adults with long-term lung conditions can get comfortable with a clinical trials unit and research team before joining future trials.

  Recruiting Richmond Pharmacology Limited · London · NCT07924462

• Breathlessness in respiratory diseases: who feels it and why

  This study tests how physiology, psychology, function, and breathing patterns relate to breathlessness in people with respiratory conditions compared with healthy controls.

  Recruiting University Hospitals, Leicester · Leicester, Leicestershire · NCT07648082

• Hypertonic saline inhalation for NTM lung disease

  This trial tests whether starting inhaled 3% hypertonic saline early helps people with non-tuberculous mycobacterial lung disease feel better and clear bacteria better, compared with starting with normal saline first.

  Recruiting Taipei Veterans General Hospital, Taiwan · Taipei · NCT07647575

• Azithromycin added to usual care to see if it lowers bronchiectasis flare-ups

  This trial tests whether taking azithromycin daily for a year reduces bronchiectasis-related flare-ups in adults with non-cystic fibrosis bronchiectasis.

  Recruiting Phase 4 Assiut University · Asyut · NCT07608328

• Bronchiectasis Phenotype Identification Model for Adults

  This study tests a baseline classifier to categorize adults with non-cystic fibrosis bronchiectasis into phenotype groups using data collected over time.

  Recruiting Assiut University · Asyut, Assiut Egypt · NCT07599969

• BASE: Aiming to test a simple, objective way to gauge bronchiectasis severity and predict flare-ups

  This study tests a new BASE framework to classify how severe non-cystic fibrosis bronchiectasis is right now and see if it can predict 12 months of worsening or flare-ups.

  Recruiting Assiut University · Asyut, Asyut Egypt · NCT07599839

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.