Cryoneurolysis vs bipolar radiofrequency ablation for knee osteoarthritis pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares two nerve-targeted treatments to relieve knee pain in adults with radiographically confirmed osteoarthritis. Participants receive either ultrasound-guided cryoneurolysis or bipolar radiofrequency ablation of the genicular nerves. Pain outcomes are measured with the Numerical Rating Scale at predefined follow-up times. The trial aims to determine which method more effectively reduces knee pain while maintaining joint stability. Eligibility requires age 40 or older, radiologic OA Kellgren-Lawrence grade III-IV, chronic pain, and a positive genicular nerve block response.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 40 years
* Symptomatic knee osteoarthritis (OA) in bladder cancer patient \[based on American College of Radiology (ACR) criteria\]
* Radiological OA (Kellgren-Lawrence grade III-IV)
* Chronic knee pain ≥ 3-6 months
* Numerical Rating Scale (NRS) ≥ 5 despite conservative treatment
* Positive diagnostic genicular nerve block (\>50% pain relief).

Exclusion Criteria:

* Prior genicular nerve ablation
* Coagulopathy
* Local infection
* Severe deformity
* Neuropathic pain syndromes
* Uncontrolled comorbidities

Where it's running

• Cairo University
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Ahmed S Abdelgalil, MD
• Email: ahmed.salah@nci.cu.edu.eg
• Phone: 00201098426689

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Unipolar vs Bipolar Radiofrequency Ablation for Knee Osteoarthritis Pain

  This study tests whether unipolar or bipolar radiofrequency ablation provides better pain relief for adults over 50 with knee osteoarthritis who have not responded to other treatments.

  Recruiting Tanta University · Tanta, El-Gharbia · NCT07789340

• Effects of virtual reality on walking in adults with knee osteoarthritis

  This study tests how immersive virtual reality environments—designed to feel safe or to provoke fear—affect walking and worry about movement in adults 50 and older with knee osteoarthritis and in healthy peers.

  Recruiting University of Primorska · Vilnius and 1 other locations · NCT07920120

• Weekly berobenatide for knee osteoarthritis in adults who are overweight or obese

  This study tests whether weekly berobenatide helps reduce knee pain and improve function, while also affecting body weight, in adults with knee osteoarthritis who are overweight or obese (with or without type 2 diabetes).

  Recruiting Phase 3 Pfizer · Birmingham, Alabama and 3 other locations · NCT07915609

• Autologous adipose-derived stem cell injections for knee osteoarthritis

  We’re testing whether injecting a patient’s own fat-derived stem cells into the knee can help people with knee OA feel less pain and move better, compared with a standard hyaluronic acid treatment.

  Recruiting at 3 sites Yonsei University · Incheon and 2 other locations · NCT07901790

• Preoperative Multimorbidity and Functional Recovery After Total Knee Arthroplasty

  This study tests whether higher burden of preoperative multimorbidity affects functional recovery after knee replacement in adults with knee osteoarthritis.

  Recruiting Balikesir Ataturk City Hospital · Balıkesir · NCT07882316

• Cartilage biomarker response to acute loading in knee OA by antiresorptive treatment status

  Researchers will test whether a 30-minute treadmill walk changes cartilage biomarkers in postmenopausal women with knee osteoarthritis, comparing those on denosumab, bisphosphonates, and those not on antiresorptives.

  Recruiting Sisli Hamidiye Etfal Training and Research Hospital · Istanbul, Istanbul · NCT07881861

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.