Cryoablation for Thyroid Tumors: Is It Safe and Effective?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study uses ultrasound-guided cryoablation to treat thyroid neoplasms, with a non-randomized approach that may also include microwave ablation as a comparator. Participants will have tumor size tracked over time and safety monitored during follow-up visits. The study aims to determine if cryoablation reduces tumor size and what adverse effects occur. Eligibility includes adults with small papillary thyroid carcinomas or benign nodules defined by ultrasound and biopsy, with specific criteria for tumor size and invasiveness. The investigation is conducted at the Chinese People’s Liberation Army General Hospital in Beijing under the lead sponsor Yukun Luo.

Why it matters

Who can join: the full rules

Inclusion Criteria:

【Group 1: Papillary Thyroid Carcinoma (PTC) patients】

1. Pre-operative ultrasound evaluation shows the maximum tumor diameter \<1 cm;
2. Papillary thyroid carcinoma (PTC) confirmed by ultrasound-guided fine-needle aspiration (FNA) biopsy;
3. Solitary PTC confirmed by pre-operative ultrasound;
4. Imaging examinations demonstrate no extrathyroidal invasion, cervical lymph node metastasis or distant metastasis.

【Group 2: Benign thyroid nodule patients】

1. Benign nodule confirmed by puncture biopsy;
2. Preoperative ultrasound confirms solid nodule with maximum diameter greater than 2 cm;
3. Patients refuse surgical treatment or cannot tolerate surgery, voluntarily receive thyroid ablation therapy and sign the informed consent form.

Exclusion Criteria:

【Group 1: Papillary Thyroid Carcinoma (PTC) patients】

* (1) Biopsy confirms high-risk subtype papillary thyroid carcinoma; (2) History of thyroid surgery or radiotherapy; (3) Complicated with malignant tumors in other sites; (4) Severe coagulation dysfunction, or patients taking oral anticoagulants who have not reached the required drug-withdrawal period; (5) Incomplete follow-up data. 【Group 2: Benign thyroid nodule patients】

  1. Patients with uncorrected psychiatric disorders or consciousness disturbance who cannot cooperate with treatment;
  2. Patients with neck extension disorders of various causes who cannot cooperate with treatment;
  3. Severe coagulation dysfunction, or patients taking oral anticoagulants who have not completed the required drug withdrawal period;
  4. Severe cardiopulmonary insufficiency and inability to lie supine for the procedure;
  5. Unrecovered recurrent laryngeal nerve injury contralateral to the lesion.

Where it's running

• Chinese People's Liberation Army General Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Yukun Luo, MD
• Email: lyk301@163.com
• Phone: 010-66939533

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.