Cryo nerve block for pain after minimally invasive lung surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study examines intercostal cryo-analgesia (ICCA), a technique that uses controlled cold to temporarily reduce nerve activity, as an addition to multimodal pain management for patients undergoing minimally invasive anatomic lung resections. Participants undergoing VATS or RATS lobectomy, segmentectomy, or pneumonectomy will receive ICCA plus standard multimodal analgesia and outcomes will be compared with those receiving standard multimodal analgesia alone. Primary outcomes include postoperative pain scores, opioid consumption, and measures of recovery and hospital stay. The trial aims to provide higher-quality comparative data than the small observational studies done so far.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients are at least 18 years or older.
2. Patients are electively scheduled to undergo minimally invasive (i.e., VATS or RATS) anatomical lung (i.e., pneumonectomy, (bi)lobectomy, or segmentectomy) resection for benign or malignant disease.
3. Proficient understanding of the consequences of enrolment by the patients.
4. Written informed consent by the patient.

Exclusion Criteria:

1. Patients with reported intolerance or hypersensitivity to the anaesthetic drug used for ICNB.
2. Patients chronically using opioids for reasons not related to the operation (i.e., more than 3 months).
3. Patients with liver failure inhibiting the systematic use of acetaminophen (i.e., paracetamol)
4. Patients with connective tissue disease.
5. Patients with comorbidities or history contra-indicating ICCA.
6. Patients who are pregnant.
7. Participation in other clinical trial(s) that may interfere with the current trial.

Where it's running

• St. Antonius Ziekenhuis
  Nieuwegein, Utrecht, Netherlands Recruiting

Study contacts

• Study coordinator: Bart Köhlen
• Email: b.kohlen@antoniusziekenhuis.nl
• Phone: +31 88 320 1108

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.