CRP tests and patient leaflets to reduce antibiotics for adults with respiratory infections in Kyrgyzstan

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicentre, open-label randomized trial will enroll adults (18–70) with acute respiratory symptoms at 14 rural and one urban primary care centres in Kyrgyzstan. Participants are randomized in a 2x3 design: patient information leaflet versus no leaflet, and one of three CRP point-of-care test thresholds (20, 40, or 60 mg/L), creating six groups. Clinicians will use CRP results and the leaflet allocation to guide antibiotic prescribing, with 21 days of blinded follow-up to monitor antibiotic use, clinical recovery, and safety. Primary outcomes include antibiotic prescribing and patient safety, and secondary outcomes include reconsultations and symptom duration.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 to 70 years with ARTI according to the attending HCW;
* Having at least one of the following respiratory symptoms lasting for less than 2 weeks (with or without a fever):

  * cough;
  * shortness of breath;
  * sore throat;
  * stuffy nose;
  * wheezing.
* Able and willing to comply with all study requirements.
* Able and willing to give informed consent.

Exclusion Criteria:

* Severely ill and in need of urgent referral where measurement of POCT CRP is not relevant or would delay the process;
* Terminally ill patients;
* Patients with known immunosuppression or severe chronic disease (HIV, liver failure, kidney failure, history of neoplastic disease, long term systemic steroid use or similar conditions as assessed by the health worker or research team);
* Patients who are not able to participate in follow-up procedures (lack of telephone etc.);
* Have taken antibiotics within 24 hours before the index consultation;
* Pregnant women;
* Unable or unwilling to provide informed consent.

Where it's running

• Sokuluk Family Medicine Center
  Sokuluk Village, Chui Region, Kyrgyzstan Recruiting
• Azim Azhybek uulu
  At-Bashy Village, Naryn Region, Kyrgyzstan Recruiting

Study contacts

• Study coordinator: Azamat Akylbekov, MD
• Email: azamatti@yahoo.com
• Phone: +996700351748

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.