Creating brain imaging reference values for the Chinese population
Establishment of Chinese Brain Charts for Individualized Diagnosis of Major Brain Diseases
Beijing Tiantan Hospital · NCT06643858
This study is collecting brain scans from over 10,000 people in China to see what normal brain development looks like at different ages, which could help improve diagnosis and treatment for brain diseases.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 10000 (estimated) |
| Ages | 6 Years to 90 Years |
| Sex | All |
| Sponsor | Beijing Tiantan Hospital (other) |
| Locations | 1 site (Beijing, Beijing) |
| Trial ID | NCT06643858 on ClinicalTrials.gov |
What this trial studies
This initiative gathers brain imaging data from over 10,000 participants across various age groups to establish normal brain imaging reference values for the Chinese population. It employs non-invasive imaging methods to evaluate changes in the blood-brain barrier and uses functional magnetic resonance imaging (fMRI) to assess brain function. The study aims to reveal population-level patterns of brain structure changes and provide comprehensive multi-dimensional functional indicators. By understanding brain development and aging in healthy individuals, the research seeks to enhance the understanding of neurological diseases and improve individualized diagnosis and treatment.
Who should consider this trial
Good fit: Ideal candidates include healthy individuals without any medical issues that would prevent them from undergoing MRI scans.
Not a fit: Patients with metal implants or contraindications to MRI examination may not benefit from this study.
Why it matters
Potential benefit: If successful, this initiative could provide critical reference values for brain health assessments, aiding in the early diagnosis and treatment of major brain diseases.
How similar studies have performed: Other studies have successfully established brain imaging reference values, but this initiative focuses specifically on the Chinese population, making it a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Healthy individuals with normal physical function who can lie supine without medical issues (e.g., no difficulty breathing, physical pain, nausea, or dizziness); 2. No claustrophobia; 3. No metal implants in the body (e.g., metal teeth, intrauterine devices, pacemakers, etc.). Exclusion Criteria: 1. Presence of metal implants in the body; 2. Individuals who have undergone aneurysm surgery or have aneurysm clips in the brain; 3. Contraindications to MRI examination; 4. Prospective cohort participants who are unable to meet follow-up requirements.
Where this trial is running
Beijing, Beijing
- Beijing Tiantan Hospital, Capital Medical University — Beijing, Beijing, China (RECRUITING)
Study contacts
- Principal investigator: Yaou Liu, Doctor — Beijing Tiantan Hospital
- Study coordinator: Yaou Liu, Doctor
- Email: yaouliu80@163.com
- Phone: +86 10-59975396
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Healthy, Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, Neurodegenerative Diseases, Cerebrovascular Diseases, Brain Charts, Individualized Diagnosis