Creating a model to predict re-fracture risk after spinal surgery for osteoporosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project utilizes advanced imaging techniques to analyze the relationship between preoperative bone marrow fat content, magnetic properties of bone, and bone strength in patients with osteoporotic spinal fractures. The goal is to develop a personalized risk assessment model for vertebral re-fracture following PVP/PKP treatments. By combining clinical risk factors with quantitative MRI parameters, the study aims to provide an objective evaluation of re-fracture risk within the first year post-surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients diagnosed with osteoporotic vertebral fractures of the thoracic and lumbar level with reference to the 2022 edition of the Osteoporotic Fractures Guidelines (2022 edition);
* The presence of bone marrow edema or hemorrhage (acute fracture) in the fractured vertebrae is clearly defined by MR examination, and the responsible vertebrae is treated with PVP / PKP;
* Number of fractured vertebrae: 1-3 vertebral compression fractures (including old fractures).

Exclusion Criteria:

* History of severe scoliosis, vertebroplasty, or internal spinal fixation;
* Presence of spinal infection and malignant neoplastic disease;
* Presence of mental disease, cognitive impairment, or critical illness (e.g., severe cardiac or cerebrovascular disease).

Where it's running

• The Seventh Affiliated Hospital, Sun Yat-sen University
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Principal investigator: qingyu liu — The Seventh Affiliated Hospital of Sun Yat-sen University
• Study coordinator: jinhui cai
• Email: caijinhui123456@163.com
• Phone: +86 18002299663

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.