Creatine supplementation to aid recovery after ischemic stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study investigates the effectiveness of creatine supplementation in enhancing physical and functional recovery in patients who have recently suffered an ischemic stroke. The study employs a randomized, double-blind design, comparing the effects of creatine monohydrate to a placebo. It aims to address the significant loss of functionality and muscle mass that stroke survivors experience, focusing on improving mobility and overall recovery outcomes. Participants will be recruited within a specific time frame post-stroke, ensuring timely intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 18 and 80 years
* Recent diagnosis of ischemic stroke (from 24 hours to 5 days) .
* Neurological deficit due to the stroke that affects mobility (paresis and/or ataxia) and requires motor rehabilitation.
* Ability to understand and sign the informed consent form, or failing that, have sufficient support to carry out the correct follow-up of the study.

Exclusion Criteria:

* Moderate-severe disability prior to stroke, defined by an mRS\>2.
* Unstable or severe clinical situation that prevents active rehabilitation.
* Neurological deficit due to stroke that prevents walking without help from another person. The use of support with a cane, crutch or walker is permitted.
* Moderate or severe dysphagia that makes therapeutic adherence difficult.
* Use of creatine supplements in the last 3 months, or use of anabolic products in the last 3 months.
* Severe kidney disease (GFR \<30ml/min/1.73 m2).
* Musculoskeletal pathology that prevents assessment of muscle strength. For example: fractures, severe osteoarthritis, ligament tears or tendinopathies.
* History of allergic reactions to creatine.
* Pregnancy or breastfeeding.
* Simultaneous participation in another clinical trial.

Where it's running

• IdISBa
  Palma de Mallorca, Balearic Islands, Spain Recruiting

Study contacts

• Principal investigator: Raquel Delgado Mederos, PhD — Fundació d'investigació Sanitària de les Illes Balears
• Study coordinator: Raquel Delgado Mederos, PhD
• Email: raquel.delgado@ssib.es
• Phone: 0034971205234

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.