Corin gene double variant (Thr555Ile and Glu568Pro) and high blood pressure risk in Afro‑Caribbean adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will compare adults of Afro‑Caribbean descent with confirmed hypertension to age‑ and sex‑matched controls without hypertension, collecting clinical blood pressure data and genetic samples. DNA will be genotyped to detect the double polymorphism in the CORIN gene (Thr555Ile and Glu568Pro) and its frequency will be compared between cases and controls. Inclusion requires participants to be over 18, affiliated with a social security plan, self‑identify as Afro‑Caribbean, and provide written consent. The goal is to determine whether the double variant is a risk marker for hypertension in this specific population, which could inform future screening or prevention strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Case inclusion criteria

* Persons affiliated with or benefiting from a social security plan;
* Over 18 years of age;
* Considering themselves to be of Afro-Caribbean descent;
* Having given their free, informed, written and signed consent (at the latest on the day of inclusion and before any examination required by the research);
* Treated for hypertension or presenting with hypertension according to recommendations: elevated blood pressure (BP), including systolic blood pressure (SBP) ≥140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg measured in the physician's office and confirmed over several visits on the day of inclusion or diagnosis made by ABPM or self-measurement.

Control inclusion criteria:

* Individuals affiliated with or benefiting from a social security plan;
* Over 18 years of age;
* Patients who consider themselves of Afro-Caribbean origin, of the same sex as the cases and ± 5 years of age, not treated for hypertension and not presenting with hypertension according to the HAS recommendations on the day of the inclusion visit. Controls will be recruited by the same GPs who included a person with hypertension, consulting for any other symptom
* Having given their free, informed, written and signed consent (at the latest on the day of inclusion and before any examination required by the research);

Exclusion Criteria:

* Minors; Pregnant or breastfeeding women; Protected persons, or persons under court protection; Refusal to participate. Patients unable to come to the laboratory

Where it's running

• Medical practice KERIB
  Petit-Bourg, Guadeloupe Recruiting
• Toncoeurtonka
  Petit-Canal, Guadeloupe Not yet recruiting

Study contacts

• Study coordinator: HEDREVILLE SEGO, Doctor
• Email: hedrevillesego.cabinet@orange.fr
• Phone: +590 590 386355

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.