Core-based movement plus nutrition for stress and metabolic health in overweight women with functional constipation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Overweight women with functional constipation will be randomly assigned to receive either core-based movement with nutritional counseling or nutritional counseling alone for 8 weeks. Primary outcomes include perceived stress, serum cortisol, and lipid profile, with secondary outcomes such as stool form, sleep quality, and health-related quality of life. Assessments occur at baseline and after the 8-week intervention and involve fasting blood tests and standardized questionnaires. The intervention combines a twice-weekly core stability program with guideline-based nutrition advice, while the control group receives the nutrition counseling alone. The study is conducted at Cairo University and Kafrelsheikh University facilities.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female participants diagnosed with functional constipation according to Rome IV diagnostic criteria.
* Age between 18 and 45 years.
* Body mass index between 25 and 29.9 kg/m².
* Ability to participate safely in the core-based movement exercise program.
* Willingness to follow the nutritional counselling program and study procedures.

Exclusion Criteria:

* Participants will be excluded if they have any organic gastrointestinal disorder or any disease that may affect gastrointestinal transit or colonic function.
* Participants with inflammatory bowel disease, concurrent infectious enteritis, malignant tumors, or a history of gastrointestinal surgery, including resection of the stomach, small intestine, or large intestine, will be excluded.
* Participants receiving steroids, antibiotics, immunosuppressive medications, or routinely using laxatives will be excluded.
* Participants with hyperthyroidism, hypothyroidism, or other endocrine or metabolic disorders that may affect gastrointestinal function will be excluded.
* Participants with serious cardiovascular, respiratory, renal, hepatic, hematological, neurological, or psychiatric disorders will be excluded.
* Participants with a history or current evidence of alcohol abuse within the previous year will be excluded.
* Participants currently engaged in an intense workout regimen will be excluded.
* Participants with a musculoskeletal disability that may interfere with exercise applicability, such as cervical or lumbar radiculopathy, will be excluded.

Where it's running

• Faculty of Physical Therapy, Kafrelsheikh University
  Kafr ash Shaykh, Kafr el-Sheikh Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Doaa M Allam, PhD
• Email: doaaallam48@gmail.com
• Phone: 01003116041

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.