Cooling treatment for newborns with hypoxic-ischemic encephalopathy in Vietnam

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers at the National Children's Hospital in Hanoi will apply standardized therapeutic hypothermia protocols to term newborns (≥36 weeks) with hypoxic-ischemic encephalopathy identified within 6 hours of birth. Clinical and paraclinical monitoring will be performed during hospitalization and brain MRI will be obtained between days 5 and 17 of life. Short-term treatment outcomes will be recorded and long-term neurological outcomes will be followed through the 2025–2028 study period. The team will also analyze factors associated with outcomes to refine technical procedures and indications for cooling.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Neonates diagnosed with hypoxic-ischemic encephalopathy (HIE) at the Neonatal Center, National Children's Hospital
* Gestational age ≥ 36 weeks
* Assessed using the modified Sarnat staging within the first 0-6 hours after birth
* Eligible for and/or treated with therapeutic hypothermia according to institutional protocol
* Underwent clinical and paraclinical monitoring during hospitalization
* Received brain magnetic resonance imaging (MRI) during the neonatal period (from 5 to 17 days of age)
* Availability of complete medical records for data collection and analysis

Exclusion Criteria:

* Presence of major congenital anomalies, particularly involving the central nervous system
* Absence of brain MRI during the study period
* Refusal of participation by parent(s) or legal guardian(s)

Where it's running

• Vietnam National Children's Hospitalv
  Ha Nội, Hanoi, Vietnam Recruiting

Study contacts

• Study coordinator: Dat Huu Tran
• Email: drtrandat1986@gmail.com
• Phone: +84987836686

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.