Continued use of DOT spectacle lenses for Chinese children
Official title: Clinical Assessment of DOT Spectacle Lenses in Chinese Children Extension
Run by SightGlass Vision, Inc. · NCT07008001 · Data updated 2026-11-12
This will test whether DOT spectacle lenses slow myopia progression over 12 months in Chinese children who completed the earlier CATHAY study.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 8 Years to 16 Years |
| Sex | All |
| Enrollment | 175 (estimated) |
| Sponsor | SightGlass Vision, Inc. Industry-sponsored |
| Locations | 5 sites (Changsha and 4 other locations) |
| Status | Recruiting |
| Started | August 1, 2025 |
| Main results expected | September 30, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | December 29, 2025 |
| Trial ID | NCT07008001 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are Chinese children who completed the CATHAY study, whose parents provide informed consent, and who can commit to wearing the assigned spectacles for at least 10 hours daily and avoiding other myopia treatments for 12 months.
✕Probably not a fit
Children with known allergies to proparacaine, tetracaine, tropicamide, or cyclopentolate, or those unable or unwilling to wear the spectacles daily or to avoid other myopia therapies, are unlikely to receive benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a 12-month, randomized, controlled, open-label, evaluator-blinded, multicenter extension enrolling Chinese children who successfully completed the CATHAY trial. Participants are randomly assigned to wear DOT spectacle lenses and are asked to wear them at least 10 hours per day while avoiding contact lenses or other myopia-control interventions. Outcome assessors are blinded, and the trial continues safety monitoring while measuring refractive change and axial length to determine lens effect on myopia progression. The study is conducted at three major ophthalmic centers in China.
Why it matters
Potential benefit: If successful, DOT lenses could slow juvenile myopia progression and help reduce the need for more invasive or intensive treatments later in life.
How similar studies have gone: This extension follows the CATHAY trial of DOT lenses, and other optical lens approaches for myopia control have shown promising but variable success in slowing childhood myopia.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Previously a successfully completed participant in the CATHAY study (NCT05562622) 2. Agree to wear the assigned spectacles constantly except for sleeping, swimming, or other activities in which spectacle wear would be dangerous or otherwise not possible (minimum of 10 hours per day) 3. Willingness to participate in the trial for 12 months without contact lens wear or any other myopia management intervention 4. The subject's parent(s) or legal guardian(s) must read, understand and sign the Statement of Informed Consent and receive a fully executed copy of the form Exclusion Criteria: 1\. Known allergy to proparacaine, tetracaine, or tropicamide or cyclopentolate
Where it's running
-
Aier Eye Hospital
Changsha, China Recruiting -
West China Hospital
Chengdu, China Recruiting -
Fudan University EENT
Shanghai, China Recruiting -
Tianjin Eye Hospital
Tianjin, China Recruiting -
Zhongshan Ophthalmic Center
Guangzhou, China Not yet recruiting
Study contacts
- Study coordinator: Jennifer S Hill, BS
- Email: jhill@sightglassvision.com
- Phone: 678-361-4877
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.