Concurrent chemotherapy with IMRT for recurrent nasopharyngeal carcinoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase III randomized controlled study aims to evaluate the effectiveness of concurrent chemotherapy using cisplatin combined with intensity-modulated radiotherapy (IMRT) in patients with locally recurrent T3/T4 nasopharyngeal carcinoma. The study compares this combination treatment to IMRT alone to determine if it improves local control of the cancer and reduces severe late toxicities. Eligible participants include those who have pathologically confirmed recurrent NPC and meet specific health criteria. The study is designed to provide insights into better treatment options for this challenging condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1.Pathologically or clinically confirmed rT3/T4 locally recurrent nasopharyngeal carcinoma;

  2.No evidence of distant metastasis

  3.More than 1 year from the end of the first course of radiotherapy

  4.Male, or female not in the phase of lactating or pregnancy

  5.ECOG 0-2

  6.Aged 18-70 years old

  7.WBC count ≥4×109/L, neutrophile granulocyte count≥1.5×109/L, PLT count ≥100×109/L, Hb ≥9g/L

  8.Total bilirubin, AST, ALT≤2.0 times of upper normal limits; creatinine ≤1.5 times of upper normal limits

  9.Written informed consort signed

Exclusion Criteria:

1. Only regionally recurrence
2. Evidence of distant metastasis
3. Prior invasive malignancy; noninvasive cancers (For example, carcinoma in situ of the bladder, oral cavity, or cervix are all permissible) are permitted
4. Severe, active co-morbidity
5. Prior anti-tumor treatment after diagnosis of local recurrence
6. MRI was not performed 3 months after the first course of radiotherapy
7. Abnormal function of heart, brain and lungs, etc
8. Lactation or pregnancy
9. Severe nasopharyngeal mucosal necrosis at the diagnosis of local recurrence

Where it's running

• WangHanYu
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Study coordinator: Fei Han, doctor
• Email: hanfei@sysucc.org.cn
• Phone: 8620-87343030

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.