Comprehensive intervention techniques for adolescent depression

Research and Application of Key Technologies for Early Identification, Risk Warning and Comprehensive Intervention of Adolescent Depression

This study is testing a new way to help teenagers with depression by combining therapy, medication, and brain stimulation to see if it improves their recovery.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 100 (estimated)
• Ages: 12 Years to 18 Years
• Sex: All
• Sponsor: First Affiliated Hospital of Zhejiang University (other)
• Locations: 1 site (Hangzhou, Zhejiang)
• Trial ID: NCT05945342 on ClinicalTrials.gov

What this trial studies

This project focuses on the early identification and comprehensive intervention of adolescent depression through a multi-faceted approach. It includes the development of a diagnostic platform utilizing artificial intelligence to assess suicide risk, the creation of a simplified interpersonal psychotherapy technique, and the application of robotic navigation for repetitive transcranial magnetic stimulation (rTMS). The study aims to combine pharmacological treatments with psychotherapy and rTMS to enhance recovery rates in adolescents suffering from depression. By integrating psychological, biological, and neuroimaging data, the project seeks to establish effective intervention models for this vulnerable population.

Who should consider this trial

Good fit: Ideal candidates for this study are adolescents diagnosed with depression who have not received recent antidepressant treatment or psychotherapy.

Not a fit: Patients with other mental disorders, severe medical conditions, or a history of substance abuse may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could significantly improve the identification and treatment of adolescent depression, leading to better clinical outcomes and reduced suicide risk.

How similar studies have performed: Other studies have shown promise in using combined therapeutic approaches for depression, but this specific intervention model is novel.

Eligibility criteria

Inclusion Criteria:

* Sign a written informed consent to participate in the trial and receive treatment;
* Meet the diagnostic criteria of depression in DSM-5, and have no psychotic characteristics;
* Child Depression Rating Scale-Revised (CRs-R)≥40 points;
* 24 Hamilton Depression Scale (HAMD-24) scores ≥20;
* First or recurrent depressive episode, not received antidepressant drugs and systematic psychotherapy in recent 2 months;
* The Han nationality, right hand

Exclusion Criteria:

* Have other mental disorders, or have a history of other mental disorders, such as attention deficit movement disorder, autism, and developmental retardation;
* Patients with current infections, trauma, autoimmune diseases, other unstable medical conditions, or who are receiving hormone therapy;
* Patients with a history of craniocerebral injury and coma;
* A family history of bipolar disorder, seizures, or epilepsy;
* Those who had substance abuse or dependence within the first three months of enrollment;
* Patients with contraindications for MRI examination such as metal foreign body in the skull or abnormal brain structure found in MRI examination.

Where this trial is running

Hangzhou, Zhejiang

• The First Affiliated Hospital of Zhejiang University — Hangzhou, Zhejiang, China (RECRUITING)

Study contacts

• Study coordinator: Huang, Manli, M.D

Conditions: Depressive Disorder, Adolescent