Comparison of radical prostatectomy and precision prostatectomy for men with low- or intermediate-risk prostate cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Eligible men will undergo either standard radical prostatectomy or precision prostatectomy at Henry Ford Health and be followed for postoperative functional and oncologic outcomes. Precision prostatectomy aims to remove >90% of prostate tissue while preserving the capsule, seminal vesicle, and contralateral nNOS-containing nerves to improve potency and continence. Primary outcomes include sexual potency (SHIM score ≥17) and urinary continence (0–1 pads/day), with PSA-based oncologic control monitored over at least 12 months. Enrollment is limited to patients with unilateral dominant disease, Gleason ≤4+3 on biopsy, PSA ≤20 ng/mL, clinical stage ≤cT2, and preoperative SHIM ≥17.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Prostate cancer patients receiving treatment at Henry Ford Health from the investigator or co-investigator who opt for surgery.
* Prostate-specific antigen (PSA) ≤20 ng/mL
* Clinical stage ≤cT2
* Dominant unilateral lesion with Gleason ≤4+3 on biopsy
* No Gleason ≥4 contralaterally
* Preoperative SHIM score ≥17 (with or without phosphodiesterase-5 inhibitor use)

Exclusion Criteria:

* • Androgen deprivation therapy within 6 months.

  * Nodal positive disease
  * Metastatic disease
  * Prior prostate cancer therapy (e.g., radiation, HIFU).
  * Significant comorbidities precluding surgery or life expectancy \<5 years as defined by the Prostate Cancer Comorbidity Index \[5\].
  * Any previous cancer diagnosis.

Where it's running

• Henry Ford Health
  Detroit, Michigan, United States Recruiting

Study contacts

• Study coordinator: Firas Abdollah, MD, FEBU
• Email: fabdoll1@hfhs.org
• Phone: 313-673-7463

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.