Comparing warm humidified CO2 and dry CO2 for pain management in bariatric surgery
Official title: Lexion AP 50/30 Warmed Humidified Real Time CO2 Insufflation vs Airseal Recirculated CO2/Air Insufflation in Minimally Invasive Bariatric (Gastric Bypass) Surgery: A Randomized Controlled Study of Clinical Evaluation
Run by The University of Texas Health Science Center, Houston · NCT05838300 · Data updated 2026-11-12
This study is testing if using warm, humidified carbon dioxide during bariatric surgery can help reduce pain and the need for pain medication afterward.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 54 (estimated) |
| Sponsor | The University of Texas Health Science Center, Houston Academic / other |
| Locations | 1 site (Houston, Texas) |
| Status | Recruiting |
| Started | May 19, 2023 |
| Main results expected | September 30, 2025 |
| Study ends | December 30, 2025 |
| Registry record updated | June 13, 2025 |
| Trial ID | NCT05838300 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults undergoing elective primary or revision bariatric surgery or hiatal hernia repair.
✕Probably not a fit
Patients who are undergoing emergency surgery, have a history of narcotics addiction, or have conditions that impair their ability to consent or understand the procedure may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the impact of warm and humidified carbon dioxide (CO2) on postoperative pain and analgesia requirements in patients undergoing laparoscopic bariatric surgery. Participants will be randomly assigned to receive either warm humidified CO2 or dry CO2 during their procedure. The primary focus is to assess whether the use of warm humidified CO2 can lead to reduced pain levels and lower the need for pain medication post-surgery. The study will include elective bariatric primary or revision procedures and hiatal hernia repairs.
Why it matters
Potential benefit: If successful, this approach could significantly reduce postoperative pain and the need for analgesics in bariatric surgery patients.
How similar studies have gone: While the use of warm humidified CO2 in surgical settings is promising, this specific approach in bariatric surgery is relatively novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * elective bariatric primary or revision procedures and hiatal hernia repair procedures for all indications. Exclusion Criteria: * emergency surgery, reoperation within 30 days * patients who are taking pain medications (narcotics) daily preoperatively for whatever reason * history of narcotics addiction * paraplegic and quadriplegic patients * dementia or altered mental status * patients on steroids * pregnant women * psychiatric patients * minors * unable to give informed consent
Where it's running
-
The University of Texas Health Science Center at Houston
Houston, Texas, United States Recruiting
Study contacts
- Principal investigator: Erik Wilson, MD, FACS — The University of Texas Health Science Center, Houston
- Study coordinator: Erik B Wilson, MD,FACS
- Email: Erik.B.Wilson@uth.tmc.edu
- Phone: 713-500-7277
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.